Dendritic Cells Have Reduced Cell Surface Membrane Glycoproteins Including CD43 Determinants
The molecular basis for the special ability of dendritic cells (DC) to stimulate primary T cell responses is at present unknown. Important accessory molecules such as the adhesion molecules LFA-3, LFA-1, ICAM-1 and ICAM-2 and probably BB1/B7 (the ligand for T cell CD28 and CTLA-4) are expressed on DC1 and contribute to the antigen presenting function of DC. However no unique co-stimulatory cell membrane molecule or secreted cytokine has been identified on DC to date. Human blood, tonsil and bone marrow DC are potent stimulators of alloimmune T lymphocyte responses. Highly purified peripheral blood CD19 positive B cells and CD14 positive monocytes may also stimulate an alloresponse from peripheral blood T cells, including those carefully depleted of endogenous antigen presenting cells; albeit a less potent one.
KeywordsPeripheral Blood CD19 Neuraminic Acid Antigen Present Function Bone Marrow Dendritic Cell CD14 Positive Monocyte
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