Dendritic Cells Have Reduced Cell Surface Membrane Glycoproteins Including CD43 Determinants

  • William Egner
  • Barry D. Hock
  • Derek N. J. Hart
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)


The molecular basis for the special ability of dendritic cells (DC) to stimulate primary T cell responses is at present unknown. Important accessory molecules such as the adhesion molecules LFA-3, LFA-1, ICAM-1 and ICAM-2 and probably BB1/B7 (the ligand for T cell CD28 and CTLA-4) are expressed on DC1 and contribute to the antigen presenting function of DC. However no unique co-stimulatory cell membrane molecule or secreted cytokine has been identified on DC to date. Human blood, tonsil and bone marrow DC are potent stimulators of alloimmune T lymphocyte responses. Highly purified peripheral blood CD19 positive B cells and CD14 positive monocytes may also stimulate an alloresponse from peripheral blood T cells, including those carefully depleted of endogenous antigen presenting cells; albeit a less potent one.


Peripheral Blood CD19 Neuraminic Acid Antigen Present Function Bone Marrow Dendritic Cell CD14 Positive Monocyte 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • William Egner
    • 1
  • Barry D. Hock
    • 1
  • Derek N. J. Hart
    • 1
  1. 1.Haematology/Immunology Research GroupChristchurch School of Medicine Christchurch HospitalChristchurchNew Zealand

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