Advertisement

Dendritic Cells: Antigen Presentation, Accessory Function and Clinical Relevance

  • Ralph M. Steinman
  • Margit Witmer-Pack
  • Kayo Inaba
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)

Abstract

Laboratories around the world, many represented here, have now elucidated the broad outlines of the dendritic cell system. Dendritic cells occupy three compartments: a) nonlymphoid tissues such as the Langerhans cells of the skin and the interstitial dendritic cells of lung and heart, b) the circulation especially the veiled cells of the afferent lymph, and c) lymphoid organs primarily the interdigitating cells of the T cell areas and thymic medulla. These pools of dendritic cells are interconnected, since nonlymphoid cells can pick up antigens and migrate into the blood or lymph and to lymphoid organs.

Keywords

Dendritic Cell Invariant Chain Accessory Function Afferent Lymph Thymic Medulla 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Freudenthal, P. S. & Steinman, R. M. Proc. Natl. Acad. Sci. 87, 7698–7702 (1990).PubMedCrossRefGoogle Scholar
  2. 2.
    Drexhage, H. A. et al. Cell. Tiss. Res. 202, 407–430 (1979).Google Scholar
  3. 3.
    Knight, S. C. et al. Eur. J. Immunol. 12, 1057–1060 (1982).PubMedCrossRefGoogle Scholar
  4. 4.
    Pugh, C. W., MacPherson, G. G. & Steer, H. W. J. Exp. Med. 157, 1758–1779 (1983).PubMedCrossRefGoogle Scholar
  5. 5.
    Bujdoso, R. et al J. Exp. Med. 170, 1285–1302 (1989).PubMedCrossRefGoogle Scholar
  6. 6.
    Inaba, K. et al. J. Exp. Med. 172, 631–640 (1990).PubMedCrossRefGoogle Scholar
  7. 7.
    Austyn, J. M. & Larsen, C. P. Transpl. 49, 1–7 (1990).CrossRefGoogle Scholar
  8. 8.
    Demetris, A. J., Murase, N. & Starzl, T. E. Lancet In Press, (1992).Google Scholar
  9. 9.
    Schuler, G. & Steinman, R. M. J. Exp. Med. 161, 526–546 (1985).PubMedCrossRefGoogle Scholar
  10. 10.
    Romani, N. et al. J. Exp. Med. 169, 1169–1178 (1989).PubMedCrossRefGoogle Scholar
  11. 11.
    Pure, E. et al. J. Exp. Med. 127, 1459–1469 (1990).CrossRefGoogle Scholar
  12. 12.
    Kampgen, E. et al. Proc. Natl. Acad. Sci. 88, 3014–3018 (1991).PubMedCrossRefGoogle Scholar
  13. 13.
    Romani, N. et al. J. Invest. Dermatol. 93, 600–609 (1989).PubMedCrossRefGoogle Scholar
  14. 14.
    Witmer-Pack, M. D. et al. J. Exp. Med. 166, 1484–1498 (1987).PubMedCrossRefGoogle Scholar
  15. 15.
    Heufler, C., Koch, F. & Schuler, G. J. Exp. Med. 167, 700–705 (1987).CrossRefGoogle Scholar
  16. 16.
    Steinman, R. M., Lustig, D. S. & Cohn, Z. A. J. Exp. Med. 139, 1431–1445 (1974).PubMedCrossRefGoogle Scholar
  17. 17.
    Katz, S. I., Tamaki, K. & Sachs, D. H. Nature 282, 324–326 (1979.PubMedCrossRefGoogle Scholar
  18. 18.
    Barclay, A. N. & Mayrhofer, G. J. Exp. Med. 153, 1666–1671 (1981).PubMedCrossRefGoogle Scholar
  19. 19.
    Hart, D. N. J. & Fabre, J. W. J. Exp. Med. 154, 347–361 (1981).PubMedCrossRefGoogle Scholar
  20. 20.
    Inaba, K. et al. J. Exp. Med. 175, 1157–1167 (1992).PubMedCrossRefGoogle Scholar
  21. 21.
    Breel, M., Mebius, R. E. & Kraal, G. Eur. J. Immunol. 17, 1555–1559 (1987).PubMedCrossRefGoogle Scholar
  22. 22.
    Agger, R. et al. J. Leuk. Biol. 52, 34–42 (1992).Google Scholar
  23. 23.
    Crowley, M., Inaba, K. & Steinman, R. M. J. Exp. Med. 172, 383–386 (1990).PubMedCrossRefGoogle Scholar
  24. 24.
    Romani, N. et al. J. Exp. Med. 169, 1153–1168 (1989).PubMedCrossRefGoogle Scholar
  25. 25.
    Steinman, R. M. et al. J. Exp. Med. 152, 1248–1261 (1980).PubMedCrossRefGoogle Scholar
  26. 26.
    Roehm, N. W. et al J. Exp. Med. 160, 679–694 (1984).PubMedCrossRefGoogle Scholar
  27. 27.
    Young, J. W. et al. J. Clin. Invest. 90, 229–237 (1992).PubMedCrossRefGoogle Scholar
  28. 28.
    Cameron, P. U. et al. Exp. Immunol. 88, 1–11 (1992).Google Scholar
  29. 29.
    Kalter, D. C. et al. J. Immunol. 146, 3396–3404 (1991).PubMedGoogle Scholar
  30. 30.
    Cameron, P. U. et al. Science In Press (1992).Google Scholar
  31. 31.
    Lechler, R. I. & Batchelor, J. R. J. Exp. Med. 155, 31–41 (1982).PubMedCrossRefGoogle Scholar
  32. 32.
    Sornasse, T. et al. J. Exp. Med. 175, 15–21 (1992).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Ralph M. Steinman
    • 1
  • Margit Witmer-Pack
    • 1
  • Kayo Inaba
    • 2
  1. 1.Laboratory of Cellular Physiology and ImmunologyThe Rockefeller UniversityNew YorkUSA
  2. 2.Department of ZoologyKyoto UniversityKyotoJapan

Personalised recommendations