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Cytogenetics and Clinical Correlations in Breast Cancer

  • Julia C. Emerson
  • Sydney E. Salmon
  • William Dalton
  • Daniel L. McGee
  • Jin-Ming Yang
  • Floyd H. Thompson
  • Jeffrey M. Trent
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 330)

Abstract

We describe an ongoing study examining the relevance of cytogenetic changes in primary and metastatic breast cancer. Tumors samples from breast cancer patients are karyotype using G-banding techniques, and all chromosomal findings, including the presence of structural and numeric clonal abnormalities, are documented in a dynamic patient data base. Information on essential clinical characteristics is collected, and patients are followed longitudinally for disease recurrence, progression, and survival. Statistical analyses will examine potential correlations between specific abnormalities and clinical features of the disease, and survival differences between patients will be examined as a function of karyotypic differences. We anticipate that this research will provide insights on the natural history of breast cancer and help direct the search for the underlying molecular mechanisms of tumor genesis and progression.

Keywords

Breast Cancer Metastatic Breast Cancer Primary Breast Cancer Structural Abnormality Cytogenetic Abnormality 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Julia C. Emerson
    • 1
  • Sydney E. Salmon
    • 1
  • William Dalton
    • 1
  • Daniel L. McGee
    • 1
  • Jin-Ming Yang
    • 1
  • Floyd H. Thompson
    • 1
  • Jeffrey M. Trent
    • 2
  1. 1.Arizona Cancer CenterUniversity of ArizonaTucsonUSA
  2. 2.University of Michigan Cancer CenterAnn ArborUSA

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