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T Cell Differentiation and Functional Maturation in Aging Mice

  • Marilyn L. Thoman
  • D. N. Ernst
  • M. V. Hobbs
  • W. O. Weigle
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 330)

Abstract

Advancing age is accompanied by changes in immune potential, frequently characterized as declines in the capacity to mount effective cell-mediated or humoral immune responses (reviewed in 1–3). Age-related functional changes can be identified earliest in the T cell compartment, therefore understanding the impact of advancing age on T cell activity may provide the key to understanding immune senescence. The expression of effector function by T cells requires their activation to cell cycle entry. The sequence of events involved in T cell activation are affected by the aging process and result in the altered T cell reactivity demonstrated in the aged.

Keywords

Spleen Cell Phorbol Myristate Acetate Aged Mouse Aged Animal Phorbol Myristate Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Marilyn L. Thoman
    • 1
  • D. N. Ernst
    • 1
  • M. V. Hobbs
    • 1
  • W. O. Weigle
    • 1
  1. 1.Department of ImmunologyResearch Institute of Scripps ClinicLa JollaUSA

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