T Cell Differentiation and Functional Maturation in Aging Mice
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Advancing age is accompanied by changes in immune potential, frequently characterized as declines in the capacity to mount effective cell-mediated or humoral immune responses (reviewed in 1–3). Age-related functional changes can be identified earliest in the T cell compartment, therefore understanding the impact of advancing age on T cell activity may provide the key to understanding immune senescence. The expression of effector function by T cells requires their activation to cell cycle entry. The sequence of events involved in T cell activation are affected by the aging process and result in the altered T cell reactivity demonstrated in the aged.
KeywordsSpleen Cell Phorbol Myristate Acetate Aged Mouse Aged Animal Phorbol Myristate Acetate
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