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The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging pp 93–106Cite as

T Cell Differentiation and Functional Maturation in Aging Mice

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 330))

Abstract

Advancing age is accompanied by changes in immune potential, frequently characterized as declines in the capacity to mount effective cell-mediated or humoral immune responses (reviewed in 1–3). Age-related functional changes can be identified earliest in the T cell compartment, therefore understanding the impact of advancing age on T cell activity may provide the key to understanding immune senescence. The expression of effector function by T cells requires their activation to cell cycle entry. The sequence of events involved in T cell activation are affected by the aging process and result in the altered T cell reactivity demonstrated in the aged.

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Author information

Authors and Affiliations

  1. Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA, 92037, USA

    Marilyn L. Thoman, D. N. Ernst, M. V. Hobbs & W. O. Weigle

Authors
  1. Marilyn L. Thoman
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  2. D. N. Ernst
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  3. M. V. Hobbs
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  4. W. O. Weigle
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Editor information

Editors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    Stringner Sue Yang Ph.D.

  2. National Institute on Aging, Bethesda, Maryland, USA

    Huber R. Warner Ph.D.

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© 1993 Springer Science+Business Media New York

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Thoman, M.L., Ernst, D.N., Hobbs, M.V., Weigle, W.O. (1993). T Cell Differentiation and Functional Maturation in Aging Mice. In: Yang, S.S., Warner, H.R. (eds) The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging. Advances in Experimental Medicine and Biology, vol 330. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2926-2_8

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  • DOI: https://doi.org/10.1007/978-1-4615-2926-2_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6270-8

  • Online ISBN: 978-1-4615-2926-2

  • eBook Packages: Springer Book Archive

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