Gene Structure and Expression in Colorectal Cancer

  • James M. Pipas
  • Kay Pogue-Geile
  • Gene G. Finley
  • Christine A. Cartwright
  • Arnold I. Meiesler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 330)


Colorectal cancer provides a unique model for the study of molecular changes that are associated with tumorigenesis. The cancer evolves as an apparent ordered sequence from a benign to a malignant lesion in histopathological recognizable stages. Since it is relatively easy to isolate tissue representing each of these stages, studies of molecular events associated with tumor progression are feasible. Such studies have shown that multiple changes in gene structure, expression and activity occur during tumorigenesis.


Colorectal Cancer Colon Carcinoma Normal Mucosa Adenomatous Polyp Colon Carcinoma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • James M. Pipas
    • 1
  • Kay Pogue-Geile
    • 1
  • Gene G. Finley
    • 2
  • Christine A. Cartwright
    • 3
  • Arnold I. Meiesler
    • 2
  1. 1.Department of Biological SciencesUniversity of PittsburghPittsburghUSA
  2. 2.Department of Medicine And VA Medical CenterUniversity of Pittsburgh School of MedicinePittsburghUSA
  3. 3.Division of Gastroenterology Department of Medicine S 069Stanford UniversityStanfordUSA

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