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The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging pp 27–43Cite as

Genetic and Molecular Basis for Cellular Senescence

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 330))

Abstract

Normal human and rodent cells in culture exhibit a finite life span at the end of which they exhibit morphological changes and cease proliferating, a process termed cellular senescence or cellular aging. Many cancer cells differ from normal cells in that they do not senesce and have an indefinite life span in culture, suggesting that alterations relating to cellular senescence are involved in the neoplastic evolution of tumor cells. Recent experimental results strongly support a genetic basis for cellular senescence. Defects in the senescence program in transformed cells can be corrected by introduction of a specific chromosome from normal cells into the abnormal cells. Using this approach, possible senescence genes have been mapped to specific chromosomes. Cell cycle control genes that regulate entry into the DNA synthetic phase of the cell cycle must be altered in senescent cells. Recent findings suggest that phosphorylation of the retinoblastoma gene is altered in senescent cells. It is possible, but not yet proven, that aging at the cellular level contributes to the aging of the individual. Therefore, an understanding of cellular senescence at the genetic and molecular levels may provide new insights into both the cancer and aging processes.

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Author information

Authors and Affiliations

  1. Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA

    J. Carl Barrett, Lois A. Annab & P. Andrew Futreal

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  1. J. Carl Barrett
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  2. Lois A. Annab
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  3. P. Andrew Futreal
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Editor information

Editors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    Stringner Sue Yang Ph.D.

  2. National Institute on Aging, Bethesda, Maryland, USA

    Huber R. Warner Ph.D.

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© 1993 Springer Science+Business Media New York

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Barrett, J.C., Annab, L.A., Futreal, P.A. (1993). Genetic and Molecular Basis for Cellular Senescence. In: Yang, S.S., Warner, H.R. (eds) The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging. Advances in Experimental Medicine and Biology, vol 330. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2926-2_3

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  • DOI: https://doi.org/10.1007/978-1-4615-2926-2_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6270-8

  • Online ISBN: 978-1-4615-2926-2

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