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Squamous Cell Cancer of the Cervix, Immune Senescence and HPV: Is Cervical Cancer an Age-Related Neoplasm ?

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The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 330))

Abstract

Relationships between cancer and aging will assume greater scientific importance over the coming decades as the number and proportion of elderly increase. Contrary to popular belief, cervical cancer remains an important disease into old age. This paper will briefly review what is known about immune senescence, cervical cancer and immune function, and the relationship between human papilloma virus and immunity, to support the hypothesis that these factors may contribute to the continued occurrence of invasive cervical cancer in the elderly.

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References

  • Butler, R.N., Gastel, B. Aging and cancer management, part ii: Research perspectives. Ca-A Ca. J. Clinicians 29:6 (1979).

    Article  Google Scholar 

  • Campoin, M.J., McCance, D.J., Cuzjic, J. Progressive potential of mild cervical atypia: Prospective cytological, colposcopic, and virological study. Lancet 1:237–240 (1986).

    Article  Google Scholar 

  • Castello, G., Esposito, G., Stellato, G., Mora, L.D., Abate, G., Germano, A. Immunological abnormalities in patients with cervical carcinoma. Gynecol. Oncol. 25:61–64 (1986).

    Article  PubMed  CAS  Google Scholar 

  • Chen, S.S., Koffler, D., Cohen, C.J. Cellular hypersensitivity in patients with squamous cell carcinoma of the cervix. Am. J. Obstet. Gynecol. 121:91–95 (1975).

    PubMed  CAS  Google Scholar 

  • Chiang, W.T., Wei, P.Y., Alexander, E.R. Circulatory and cellular immune responses to squamous cell carcinoma of the cervix. Am. J. Obstet. Gynecol. 126:116–121 (1976).

    PubMed  CAS  Google Scholar 

  • deVilliers, E.M., Wagner, D., Schneider, A., Wesch, H., Kiklaw, H., Wahrendorf, J., Papendick, U., Zur Hausen, H. Human papillomavirus infections in women with and without abnormal cervical cytology. Lancet 2:703–705 (1987).

    Article  CAS  Google Scholar 

  • Fraumeni, J.F. Jr, Hoover, R. Immuno-surveillance and cancer: epidemiologic observations. Natl. Cancer Inst. Monogr. 47:121–126(1977).

    PubMed  Google Scholar 

  • Goldstein, M.S., Shore, B., Gusberg, S.B. Cellular immunity as a host response to squamous carcinoma of the cervix. Am. J. Obstet. Gynecol. 111:751–755 (1971).

    PubMed  CAS  Google Scholar 

  • Grubb, G.S. Human papillomavirus and cervical neoplasia: Epidemiological considerations. International Journal of Epidemiology 15:1–7 (1986).

    Article  PubMed  CAS  Google Scholar 

  • Ishiguro, T., Sugitachi, I., Katoh, K. T and B lymphocytes in patients with squamous cell carcinoma of the uterine cervix. Gynecol. Oncol. 9:80–85 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Kay, M.M.B. The effects of aging on immune function. In Waters, H. ed., The Handbook of Cancer Immunology. Garland STPM Press, New York, Volume I, pp. 63–93 (1978).

    Google Scholar 

  • Koss, L.G., Durfee, G.R. Unusual patterns of squamous epithelium of the uterine cervix: Cytologic and pathologic study of koilocytotic atypia. Ann. N.Y. Acad. Sci. 63:1245–1261 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Koss, L.G. Cytologie and histologie manifestations of human papillomavirus infection of the female genital tract and their clinical significance. Cancer 60:1942–1950 (1987).

    Article  PubMed  CAS  Google Scholar 

  • Levy, S., Kopersztych, S., Musatti, C.C., Souen, J.S., Salvatore, C.A., Mendes, N.F. Cellular immunity in squamous cell carcinoma of the uterine cervix. Am. J. Obstet. Gynecol. 130:160–164 (1978).

    PubMed  CAS  Google Scholar 

  • Mandelblatt, J.S., Gopaul, I., Wistreich, M. Gynecological care of elderly women in a primary care setting: Another look at Papanicolaou smear testing. J. Amer. Medical Assoc. 256:367–371 (1986).

    Article  CAS  Google Scholar 

  • Meanwell, C., Cox, M., Blackledge, G., Maitland, N. HPV 16 DNA in normal and malignant cervical epithelium: implications for the aetioogy and behaviour of cervical neoplasia. Lancet: 1:703–707 (1987).

    Article  PubMed  CAS  Google Scholar 

  • Meisels, A., Fortin, R. Condylomatous lesions of the cervix and vagina: Cytologie patterns. Acta Cytol. (Baltimore) 20:505–509 (1976).

    PubMed  CAS  Google Scholar 

  • Morris, H.H.B., Gatter, K.C., Sykes, G., Casemore, V. Langerhans’s cells in human cervical epithelium: Effects of wart virus infection and intraepthelial neoplasia. British J. of Obstet. and Gynec. 90:412–420 (1983).

    Article  CAS  Google Scholar 

  • Muller, C.M., Mandelblatt, J., Schecther, C. The Costs Effectiveness of Screening for Cervical Cancer in Elderly Women. In the OTA’s Series on Preventive Services Under Medicare. Health Program, Office of Technology Assessment, U.S. Congress, Washington, DC, February, 1990.

    Google Scholar 

  • Porreco, R., Penn, I., Droegemueller, W., Greer, B., Makowski, E. Gynecologic malignancies in immunosuppressed organ homograft recipients. Obstet. Gynecol. 45:359–364 (1975).

    PubMed  CAS  Google Scholar 

  • Purola, E., Savia, E. Cytology of gynecologic Condyloma acuminatum. Acta Cytol. (Baltimore) 21:26–31 (1977).

    PubMed  CAS  Google Scholar 

  • Reeves, W.C., Brinton, L.A., Garcia, M., Brenes, M.M., Herrero, R., Gaitan, E., Tenorio, F., de Britton, R.C., Rawls, W.E. Human papillomavirus infection and cervical cancer in Latin America. New Engl. J. Med. 320:1437–1441 (1989).

    Article  PubMed  CAS  Google Scholar 

  • Reid, R., Laverty, C.R., Coppleson, M., Isarangkul, W., Hills, E. Noncondylomatous cervical wart virus infection. Obstet. Gynecol. 55:476–483 (1980).

    PubMed  CAS  Google Scholar 

  • Schneider, A., Kraus, H., Schuhmann, R., Gissmann, L. Papillomavirus infection of the lower genital tract. Int. J. Cancer 35:443–446 (1985).

    Article  PubMed  CAS  Google Scholar 

  • Schneider, A., Hotz, M., Gissmann, L. Prevalence of genital HPV infections in pregnant women. In Cold Spring Harbor Symposium on Papillomaviruses (1986).

    Google Scholar 

  • Schneider, A., Sawada, E., Gissman, L., Shah, K. Human papillomaviruses in women with a history of abnormal Papanicolaou smears and in their male partners. Obstet. and Gynecol. 69:554–562 (1987).

    CAS  Google Scholar 

  • Schneider, A., Kay, S., Lee, H.M. Immunosuppression: High risk factor for the development of Condyloma acuminata and squamous neoplasia of the cervix. Acta Cytol. (Baltimore) 27:220–224 (1983).

    PubMed  CAS  Google Scholar 

  • Shokri-Tabibzadeh, S., Koss, L., Molnar, J., Romney, S. Association of human papillomavirus with neoplastic processes in genital tract of four women with impaired immunity. Gynecol. Oncol. 12:S129–S140 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Sillman, F., Stanek, A., Sedlis, A., Rosenthal, J., Lanks, K.W., Buchhagen, D., Nicastri, A., Boyce, J. The relationship between human papillomavirus and lower genital intraepithelial neoplasia in immunosuppressed women. American Journal of Obstetrics and Gynecology 150:300–308 (1984).

    PubMed  CAS  Google Scholar 

  • Streilein, J.W., Bergstresser, P.R. Ia antigens and epidermal Langerhans cells. Transplantation 30:319–323 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Syrjanen, K., Parkinen, S., Mantyjarni, R., Vayrynen, M., Syrjanen, S., Holopainen, H., Saarikoski, S., Castren, O. Human papillomavirus (HPV) type as an important determinant of the natural history of HPV infections in uterine cervix. Eur. J. Epidemiol. 1:180–187 (1985).

    Article  PubMed  CAS  Google Scholar 

  • Tay, S.K., Jenkins, D., Maddox, P., Campoin, M., Singer, A. Subpopulations of Langerhan’s cells in cervical neoplasia. British J. of Obstet, and Gynecol. 94:10–15 (1987).

    Article  CAS  Google Scholar 

  • Urban, J.L., Schreiber, H. Rescue of the tumor-specific immune response of aged mice in vitro. J. of Immunology 133:527–534 (1984).

    CAS  Google Scholar 

  • Weksler, M.E. Age-associated changes in the immune response. J. Amer. Geriatrics Soc. 30:718–723 (1982).

    CAS  Google Scholar 

  • zur Hausen, H. Human papillomavirus and their possible role in squamous cell carcinomas. Curr. Topics Microbiol. Immunol. 78:1–30 (1977).

    Article  Google Scholar 

  • zur Hausen, H. Human Genital Cancer: Synergism between two virus infections or synergism between a virus infection and initiating events? Lancet 2:1370–1372 (1982).

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Cancer Control, Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, USA

    Jeanne Mandelblatt

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  1. Jeanne Mandelblatt
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Editor information

Editors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    Stringner Sue Yang Ph.D.

  2. National Institute on Aging, Bethesda, Maryland, USA

    Huber R. Warner Ph.D.

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© 1993 Springer Science+Business Media New York

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Mandelblatt, J. (1993). Squamous Cell Cancer of the Cervix, Immune Senescence and HPV: Is Cervical Cancer an Age-Related Neoplasm ?. In: Yang, S.S., Warner, H.R. (eds) The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging. Advances in Experimental Medicine and Biology, vol 330. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2926-2_2

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  • DOI: https://doi.org/10.1007/978-1-4615-2926-2_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6270-8

  • Online ISBN: 978-1-4615-2926-2

  • eBook Packages: Springer Book Archive

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