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Glucocorticoid Receptors in Leukemias, Lymphomas and Myelomas of Young and Old

  • Javed Ashraf
  • E. Brad Thompson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 330)

Abstract

Glucocorticoids are well-known for their strong suppressive influence on certain cells of the immune system. These pharmacologic effects have long been taken advantage of to suppress immune responses and to treat leukemia and lymphomas. In recent years, a great deal has been learned of the mechanisms by which glucocorticoids affect lymphoid and related cells, and this information now provides a basis for studying the varying susceptibility to glucocorticoid therapy of the leukemias, lymphomas and myelomas in young and older patients. Expression of glucocorticoid receptors themselves is sometimes used as one predictive variable (Bloomfield, 1984; Thompson et al., 1985; Iacobelli et al., 1987). In this brief overview, we will outline the general pattern of expression with age of these groups of malignancies, discuss the recently established principles of glucocorticoid action, and describe some of our own experience with glucocorticoid effects on certain malignant lymphoid cell lines in vitro.

Keywords

Glucocorticoid Receptor Glutamine Synthetase Steroid Receptor Mouse Mammary Tumor Virus Thyroid Hormone Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Javed Ashraf
    • 1
  • E. Brad Thompson
    • 1
  1. 1.Department of Human Biological Genetics and ChemistryUniversity of Texas Medical BranchGalvestonUSA

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