Significance of Chromosomal Changes in Patients of Different Age Groups with Acute Leukemia

  • Jacqueline Whang-Peng
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 330)


Chromosome abnormalities have been observed in about 50% of patients with acute leukemia. There have been several published reports which emphasized the chromosomal changes in relation to the age of the patient and the morphologic type of acute leukemia. All observations suggest that there are both age related similarities and differences. The karyotype is an important independent prognostic factor in acute leukemia; however, age alone (especially above age 70) is the single most important factor for a poor prognosis.


Acute Lymphocytic Leukemia Chromosomal Abnormality Acute Leukemia Polycythemia Vera Blast Crisis 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Jacqueline Whang-Peng
    • 1
  1. 1.Cytogenetic Oncology Section, Medicine Branch Division of Cancer TreatmentNational Cancer InstituteBethesdaUSA

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