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Heparin-Binding Fibroblast Growth Factors and Prostate Cancer

  • Wallace L. McKeehan
  • Jinzhao Hou
  • Pamela Adams
  • Fen Wang
  • Guo-Chen Yan
  • Mikio Kan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 330)

Abstract

Studies of model rat prostate tissue and derived cells indicate the insulin-like (IGF), epidermal growth factor (EGF), transforming growth factor beta (TGF-β) and heparin-binding fibroblast growth factor (HBGF) families and their receptors may play important roles in regulation of normal prostate cell growth. Tumor cells at different levels in the progression from slow-growing, hormone-dependence to fast-growing, hormone-independence exhibit distinct alterations in expression of specific growth factors and their receptor phenotype. Distinct IGF-I and HBGF mRNAs are constitutively expressed in the mesenchymal cells of slow-tumors, but alteration in HBGF receptor phenotype occurs in the epithelial cells. Fast-tumors exhibit even higher constitutive expression of multiple HBGFs. Splice variants in cDNA for the HBGF receptor in fast-tumors suggest constitutive expression of an intracellular receptor, that together with intracellular HBGFs, may constitute an intracellular autocrine system that is independent of exogenous hormones and growth factors.

Keywords

Prostate Cell Polypeptide Growth Factor Dorsal Prostate Predict Translation Product Prostate Tumor Progression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Wallace L. McKeehan
    • 1
  • Jinzhao Hou
    • 1
  • Pamela Adams
    • 1
  • Fen Wang
    • 1
  • Guo-Chen Yan
    • 1
  • Mikio Kan
    • 1
  1. 1.W. Alton Jones Cell Science Center, Inc.Lake PlacidUSA

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