Abstract
The deoxyglucose method for calculation of regional cerebral glucose metabolism using 18F-2-fluoro-2-deoxy-D-glucose (FDG) as a tracer (1,2) requires knowledge of differences in the transport of FDG and glucose across the blood-brain barrier (BBB), as well as affinity for the enzyme hexokinase, in the first step of the glycolysis. These differences are incorporated in a correction term, the lumped constant. The unique feature of the PET-FDG method is the ability to measure the absolute metabolic rate of glucose, but the correct estimation of the lumped constant has been a major problem. Few methods for estimation of the lumped constant have so far been put forward (1, 3, 4). Simultaneous measurements of the transport of FDG and glucose across the BBB have been performed in animals (5,6), but never before in humans.
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© 1993 Springer Science+Business Media New York
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Hasselbalch, S., Knudsen, G.M., Jakobsen, J., Holm, S., Paulson, O.B. (1993). Estimation of Unidirectional Clearances of FDG and Glucose Across the Blood-Brain Barrier in Man. In: Drewes, L.R., Betz, A.L. (eds) Frontiers in Cerebral Vascular Biology. Advances in Experimental Medicine and Biology, vol 331. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2920-0_5
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DOI: https://doi.org/10.1007/978-1-4615-2920-0_5
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