Abstract
Experimental allergic encephalomyelitis (EAE) is an organ-specific disease, mediated by T cells trafficking into the central nervous system (CNS) (1). EAE has served as a model system for the human demyelinating disease, multiple sclerosis (MS) (2). The mechanisms regulating the tissue tropism in organ-specific diseases such as MS are under intense investigation. Local antigen presentation (i.e., myelin basic protein), by blood-brain barrier-derived cells (endothelial cells, perivascular microglia, astrocytes), can contribute to a selective localization of T cells into the CNS (3). Expression of CNS-specific adhesion molecules, or localized CNS upregulation of systemic adhesion molecules, could also facilitate T cell trafficking into the CNS.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Raine, C.S., Canella, B., Duijvestijn, A.M., and Cross, A.H., Homing to central nervous system vasculature by antigen specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination, Lab. Invest. 63: 476, 1990.
Alvord, E.C., Kies, M.W., and Suckling, A.J., Experimental allergic encephalomyelitis: a useful model for multiple sclerosis, Prog. Clin. Biol. Res. 146: 1, 1984.
McCarron, R.M., Kempski, O., Spatz, M., and McFarlin, D.E., Interaction of myelin basic protein sensitized T lymphocytes and murine cerebral vascular endothelial cells, J. Immunol. 134: 310, 1984.
Streeter, P.R., Berg, E.L., Rouse, B.T.N., Bargatze, R.F., and Butcher, E.C., A tissue specific endothelial cell molecule involved in lymphocyte homing, Nature 331: 41, 1988.
Berg, EX., Yoshino, T., Rott, L.S., Robinson, M.K., Warnock, A., Kishimoto, T.K., Picker, L.J., and Butcher, E.C. The cutaneous antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1, J. Exp. Med. 174: 1461, 1991.
Springer, T.A., Adhesion receptors of the immune system, Nature 346: 425, 1990.
Auerbach, R., Alby, L., Morrissey, L.W., Tu, M., and Joseph, J., Expression of organ specific antigens on capillary endothelial cells, Microvasc. Res. 29: 401, 1985.
Rupnick, M.A., Carey, A., and Williams, S.K., Phenotypic diversity in cultured cerebral microvascular endothelial cells, In Vitro 24: 435, 1988.
Wagner, R.C., and Matthews, M.A., The isolation and culture of capillary endothelium from epididymal fat, Microvasc. Res. 20: 280, 1975.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Joseph, J., Nunez, M., Grun, J.L., Lublin, F.D., Hart, M.N., Knobler, R.L. (1993). Generation of an Anti-Mouse Brain Endothelial Cell Monoclonal Antibody that Recognizes 84-110 kDa and 36 kDa Determinants that are Upregulated by Cytokines. In: Drewes, L.R., Betz, A.L. (eds) Frontiers in Cerebral Vascular Biology. Advances in Experimental Medicine and Biology, vol 331. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2920-0_39
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2920-0_39
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6267-8
Online ISBN: 978-1-4615-2920-0
eBook Packages: Springer Book Archive