Abstract
The development of resistance to multiple chemotherapeutic drugs is a major obstacle in the clinical treatment of many human cancers. Cultured cells grown in medium containing selected drugs can acquire cross resistance to a remarkably wide range of compounds that have no obvious structural or functional similarities (1). A multidrug resistance (MDR) phenotype has been described, which consists of the amplification of members of a small gene family and the increased synthesis of a 4.5-6.0 kb mRNA (2, 3). These alterations are associated with the overexpression of a glycoprotein (P-glycoprotein or P-gp) of relative molecular mass (Mr) 170, 000-180, 000 (4). P-gp is likely to function as an energy-dependent drug efflux pump (5) and to possess notable similarities with bacterial transport proteins (6).
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Jetté, L., Béliveau, R. (1993). P-Glycoprotein is Strongly Expressed in Brain Capillaries. In: Drewes, L.R., Betz, A.L. (eds) Frontiers in Cerebral Vascular Biology. Advances in Experimental Medicine and Biology, vol 331. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2920-0_20
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