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Alterations in Brain Glucose Transporter Proteins, Glut1 and Glut3, in Streptozotocin Diabetic Rats

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Book cover Frontiers in Cerebral Vascular Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 331))

Abstract

The brain is dependent on glucose for energy, and it requires glucose transporter proteins to facilitate the passage of glucose across the blood-brain barrier and across the plasma membranes of neurons and glia. Two glucose transporter isoforms, GLUT1 and GLUT3, have been identified in rat brain. GLUT1 is detected as a 55 kDa form associated with microvessels and a 45kDa form associated with microvessel-free cerebral membranes. GLUT3, the neuronal glucose transporter (2, 6) is expressed in most brain regions and the neurohypophysis (3).

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References

  1. Harik S.I., Gravina, S.A., and Kalaria, R.N., Glucose transporter of the blood-brain barrier and brain in chronic hyperglycemia, J. Neurochem. 51: 1930–1934, 1988.

    Article  PubMed  CAS  Google Scholar 

  2. Maher, F., Davies-Hill, T.D., Lysko, P.G., Henneberry, R.C., and Simpson, I.A., Expression of two glucose transporters, GLUT1 and GLUT3, in cultured cerebellar neurons: evidence for neuron-specific expression of GLUT3, Mol. Cell Neurosci. 2: 351–360, 1991.

    Article  PubMed  CAS  Google Scholar 

  3. Maher, F., Vannucci, S.J., Takeda, J., and Simpson, I.A., Expression of mouse-GLUT3 and human-GLUT3 glucose transporter proteins in brain, Biochem. Biophys. Res. Commun. 182: 703–711, 1992.

    Article  PubMed  CAS  Google Scholar 

  4. Mans, A.M., DeJoseph, M.R., Davis, D.W., and Hawkins, R.A., Brain energy metabolism in streptozotocin-diabetes, Biochem.J. 249: 57–62, 1988.

    PubMed  CAS  Google Scholar 

  5. McCall, A.L., The impact of diabetes on the CNS, Diabetes 41: 557–570, 1992.

    Article  PubMed  CAS  Google Scholar 

  6. Nagamatsu, S., Kornhauser, J.M., Burant, C.F., Seino, S., Mayo, K.E., and Bell, G.I., Glucose transporter expression in brain: cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization, J. Biol. Chem. 267: 467–472, 1992.

    PubMed  CAS  Google Scholar 

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© 1993 Springer Science+Business Media New York

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Maher, F., Simpson, I.A., Vannucci, S.J. (1993). Alterations in Brain Glucose Transporter Proteins, Glut1 and Glut3, in Streptozotocin Diabetic Rats. In: Drewes, L.R., Betz, A.L. (eds) Frontiers in Cerebral Vascular Biology. Advances in Experimental Medicine and Biology, vol 331. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2920-0_2

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  • DOI: https://doi.org/10.1007/978-1-4615-2920-0_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6267-8

  • Online ISBN: 978-1-4615-2920-0

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