Abstract
The brain is dependent on glucose for energy, and it requires glucose transporter proteins to facilitate the passage of glucose across the blood-brain barrier and across the plasma membranes of neurons and glia. Two glucose transporter isoforms, GLUT1 and GLUT3, have been identified in rat brain. GLUT1 is detected as a 55 kDa form associated with microvessels and a 45kDa form associated with microvessel-free cerebral membranes. GLUT3, the neuronal glucose transporter (2, 6) is expressed in most brain regions and the neurohypophysis (3).
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References
Harik S.I., Gravina, S.A., and Kalaria, R.N., Glucose transporter of the blood-brain barrier and brain in chronic hyperglycemia, J. Neurochem. 51: 1930–1934, 1988.
Maher, F., Davies-Hill, T.D., Lysko, P.G., Henneberry, R.C., and Simpson, I.A., Expression of two glucose transporters, GLUT1 and GLUT3, in cultured cerebellar neurons: evidence for neuron-specific expression of GLUT3, Mol. Cell Neurosci. 2: 351–360, 1991.
Maher, F., Vannucci, S.J., Takeda, J., and Simpson, I.A., Expression of mouse-GLUT3 and human-GLUT3 glucose transporter proteins in brain, Biochem. Biophys. Res. Commun. 182: 703–711, 1992.
Mans, A.M., DeJoseph, M.R., Davis, D.W., and Hawkins, R.A., Brain energy metabolism in streptozotocin-diabetes, Biochem.J. 249: 57–62, 1988.
McCall, A.L., The impact of diabetes on the CNS, Diabetes 41: 557–570, 1992.
Nagamatsu, S., Kornhauser, J.M., Burant, C.F., Seino, S., Mayo, K.E., and Bell, G.I., Glucose transporter expression in brain: cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization, J. Biol. Chem. 267: 467–472, 1992.
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© 1993 Springer Science+Business Media New York
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Maher, F., Simpson, I.A., Vannucci, S.J. (1993). Alterations in Brain Glucose Transporter Proteins, Glut1 and Glut3, in Streptozotocin Diabetic Rats. In: Drewes, L.R., Betz, A.L. (eds) Frontiers in Cerebral Vascular Biology. Advances in Experimental Medicine and Biology, vol 331. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2920-0_2
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DOI: https://doi.org/10.1007/978-1-4615-2920-0_2
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