Abstract
In adult mammals, acute plasma hyperosmolality causes brain shrinkage but because of the uptake of solute into brain from either blood, across the blood-brain barrier (BBB), or CSF, (4, 5, 16) or the generation of idiogenic osmoles, there is some degree of brain volume regulation. In addition, brain cells are themselves capable of volume regulation. This again involves the uptake and loss of solute, in particular Na+, K+, Cl-, and amino acids (13,15).
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Keep, R.F., Xiang, J., Ennis, S.R., Beer, M.E., Betz, A.L. (1993). Brain Volume Regulation During Development: The Role of Blood-Brain Barrier Potassium Transport. In: Drewes, L.R., Betz, A.L. (eds) Frontiers in Cerebral Vascular Biology. Advances in Experimental Medicine and Biology, vol 331. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2920-0_11
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DOI: https://doi.org/10.1007/978-1-4615-2920-0_11
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