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NADH-Cytochrome b5 Reductase and Cytochrome b5 the Problem of Posttranslational Targeting to the Endoplasmic Reticulum

  • Chapter
Endoplasmic Reticulum

Part of the book series: Subcellular Biochemistry ((SCBI,volume 21))

Abstract

A large number of endoplasmic reticulum (ER) enzymes, many of which are involved in the metabolism of lipids and drugs, have a cytosolically exposed active site and only a small lumenal domain (or possibly no lumenal amino acid residues at all) so that large portions of their polypeptide chain must not be translocated across the ER membrane. The biosynthesis of this class of proteins, their mechanism of targeting to the ER and of correct insertion into the phospholipid bilayer, represents an important aspect of ER biogenesis.

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Authors and Affiliations

  1. CNR Center for Cytopharmacology and Department of Pharmacology, University of Milan, Milan, Italy

    Nica Borgese, Antonello D’Arrigo, Marcella De Silvestris & Grazia Pietrini

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  1. Nica Borgese
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  2. Antonello D’Arrigo
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  3. Marcella De Silvestris
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  4. Grazia Pietrini
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Editors and Affiliations

  1. CNR Center for Cytopharmacology, University of Milan, Milan, Italy

    N. Borgese

  2. Institute of Zoology, University of Mainz, Mainz, Germany

    J. R. Harris

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© 1993 Springer Science+Business Media New York

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Borgese, N., D’Arrigo, A., De Silvestris, M., Pietrini, G. (1993). NADH-Cytochrome b5 Reductase and Cytochrome b5 the Problem of Posttranslational Targeting to the Endoplasmic Reticulum. In: Borgese, N., Harris, J.R. (eds) Endoplasmic Reticulum. Subcellular Biochemistry, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2912-5_14

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  • DOI: https://doi.org/10.1007/978-1-4615-2912-5_14

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