Skip to main content

The Immune Response in Protein-Energy Malnutrition and Single Nutrient Deficiencies

  • Chapter

Part of the book series: Human Nutrition ((HUNU))

Abstract

Protein-energy malnutrition (PEM) (undernutrition or overnutrition) is one of the nutritional problems recognized by the WHO as public health problems in different parts of the world. The others are nutritional anemias, vitamin A deficiency, and iodine deficiency. Primary PEM (undernutrition) has long been regarded as a problem of underprivileged, low-socioeconomic groups, especially those from less developed countries. Although severe malnutrition (kwashiorkor and/or marasmus) are rare except in countries hit by natural disasters such as drought and war, mild and moderate malnutrition are quite common. The prevalence of this form of malnutrition varies from 21 to 70% depending on the continent and/or country (Rao and Naider, 1977; Suskind et al., 1990). This form of malnutrition may not be any less deleterious on the immune response than severe malnutrition, especially when it occurs in the context of poor sanitation, infections, and multiple nutritional deficiencies.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahmed, F., Jones, D. B., and Jackson, A. A., 1990, Effect of undernutrition on the immune response to rotavirus infection in mice, Ann. Nutr. Metab. 34: 21–31.

    Article  CAS  Google Scholar 

  • Alam, N., Wojtymiak, B., and Rahaman, M. M., 1989, Anthropometric indicators and risk of death, Am. J. Clin. Nutr. 49: 884–888.

    CAS  Google Scholar 

  • Allen, J. I., Perri, R. T., McClain, C. J., and Kay, N. E., 1983, Alterations in human natural killer cell activity and monocyte cytotoxicity induced by zinc deficiency, J. Lab. Clin. Med. 102: 577–589.

    CAS  Google Scholar 

  • Anderson, R., Oosthuizen, R., Maritz, R., Theron, A., and Van Rensberg, A. J., 1980, The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers, Am. J. Clin. Nutr. 33: 71–76.

    CAS  Google Scholar 

  • Anthony, L. E., Kurahara, C. G., and Taylor, K. B., 1979, Cell-mediated cytotoxicity and humoral immune response in ascorbic acid deficient guinea pigs, Am. J. Clin. Nutr. 32: 1691–1698.

    CAS  Google Scholar 

  • Bagchi, K., Mohanson, M., and Reddy, V., 1980, Humoral immune response in children with iron deficiency anemia, Br. Med. J. 1: 1249–1251.

    Article  Google Scholar 

  • Barbul, A., Rettura, G., Levenson, S. M., and Seifter, E., 1977, Arginine: Thymotropic and wound healing promoting agent, Surg. Forum 28: 101–103.

    CAS  Google Scholar 

  • Barbul, A., Wasserkrug, H. L., Seifter, E., et al., 1981, Immunostimulatory effects of arginine in normal and injured rats, J. Surg. Res. 29: 228–235.

    Article  Google Scholar 

  • Barbul, A., Sisto, D. A., Wasserkrug, H. L., and Efron, G., 1981, Arginine stimulates lymphocyte-immune response in healthy humans, Surgery 90: 244–251.

    CAS  Google Scholar 

  • Beach, R. S., Gershwin, M. E., and Hurley, L. S., 1982, Gestational zinc deprivation in mice. Persistence of immunodeficiency for three generations, Science 218: 469–472.

    Article  CAS  Google Scholar 

  • Bendich, A., Gabriel, E., and Machlin, L. F., 1985, Role of dietary vitamin E on natural killer cell lysis, Proc. XIIIth Int. Congr. Nutr., Brighton, p. 77.

    Google Scholar 

  • Bendich, A., Gabriel, E., and Machlin, L. J., 1986, Dietary vitamin E requirement for optimum immune responses in the rat, J. Nutr. 116: 675–681.

    CAS  Google Scholar 

  • Bhaskaram, P., 1985, Immune response and infection in relation to vitamin A and iron deficiency in children, Proc. XIIIth Int. Congr. Nutr., Brighton: pp. 132-135.

    Google Scholar 

  • Bhaskaram, P., and Reddy, C., 1975, Cell-mediated immunity in iron and vitamin A deficient children, Br. Med. J. 3: 522.

    Article  CAS  Google Scholar 

  • Bhaskaram, P., and Sivakumar, B., 1986, Interleukin-1 in malnutrition, Arch. Dis. Child. 61: 182–185.

    Article  CAS  Google Scholar 

  • Bhaskaram, P., Madhusudham, J., Radhakrishna, K. V., and Reddy, V., 1986, Immune response in malnourished children with measles, J. Trop. Pediatr. 32: 123–126.

    Article  CAS  Google Scholar 

  • Bogden, J. D., Oleske, J. M., Munves, E. M., Lavenhar, M. A., Bruening, K. S., Kemp, F. W., Holding, K. J., Denny, T. N., and Louria, D. B., 1987, Zinc and immunocompetence in the elderly: Baseline data on zinc nutriture and immunity in unsupplemented subjects, Am. J. Clin. Nutr. 46: 101–109.

    CAS  Google Scholar 

  • Bogden J. D., Oleske, J. M., Lavenhar, M. A., Munves, E. M., Kemp, F. W., Bruening, K. S., Holding, K. J., Denny, T. N., Guarino, M. A., Krieger, L. M., and Holland, B. K., 1988, Zinc and immunocompetence in elderly people: Effects of zinc supplementation for 3 months, Am. J. Clin. Nutr. 48: 655–663.

    CAS  Google Scholar 

  • Bruce-Chwatt, L. J., 1985, Malnutrition, refeeding and malaria, Br. Med. J. 291: 1574.

    Article  Google Scholar 

  • Carpentieri, M., Smith, L., Daeschner, C. W., and Haggard, M. E., 1983, Neutrophils and zinc in infection-prone children with sickle cell disease, Pediatrics 72: 88–92.

    CAS  Google Scholar 

  • Castillo-Duran C., Heresi, G., Fisberg, M., and Uauy, R., 1987, Controlled trial of zinc supplementation during recovery from malnutrition: Effects on growth and immune function, Am. J. Clin. Nutr. 45: 602–608.

    CAS  Google Scholar 

  • Chandra, R. K., 1972, Immunocompetence in undernutrition, J. Pediatr. 81: 1184–1200.

    Google Scholar 

  • Chandra, R. K., 1975a, Reduced secretory antibody response to live attenuated measles and poliovirus vaccines in malnourished children, Br. Med. J. 2: 583–585.

    Article  CAS  Google Scholar 

  • Chandra, R. K., 1975b, Fetal malnutrition and postnatal immunocompetence, Am. J. Dis. Child. 129: 450–454.

    CAS  Google Scholar 

  • Chandra, R. K., 1977, Serum complement components in malnourished Indian children in: Malnutrition and the Immune Response (R. M. Suskind, ed.), Raven Press, New York, pp. 329–332.

    Google Scholar 

  • Chandra, R. K., 1979a, Nutritional deficiency and susceptibility to infection, Bull. WHO 57(2): 167–177.

    CAS  Google Scholar 

  • Chandra, R. K., 1979b, Serum thymic hormone activity in protein-energy malnutrition, Clin. Exp. Immunol. 38: 228–230.

    CAS  Google Scholar 

  • Chandra, R. K., 1981a, Immune response in overnutrition, Cancer Res. 41: 3795–3796.

    CAS  Google Scholar 

  • Chandra, R. K., 1981b, Serum thymic hormone activity and cell-mediated immunity in healthy neonates, preterm infants and small-for-gestational age infants, Pediatrics 67: 407–411.

    CAS  Google Scholar 

  • Chandra, R. K., 1986, Serum levels and synthesis of IgG subclasses in small-for-gestational low birth weight infants and in patients with selective IgA deficiency, Monogr. Allergy 20: 90–99.

    CAS  Google Scholar 

  • Chandra, R. K., and Au, B., 1981, Single nutrient deficiency and cell-mediated immunity. III. Vitamin A, Nutr. Res. 1: 181–185.

    Article  CAS  Google Scholar 

  • Chandra, R. K., and Dayton, D. H., 1982, Trace element regulation of immunity and infection, Nutr. Res. 2: 721–733.

    Article  CAS  Google Scholar 

  • Chandra, R. K., and Gupta, S. P., 1991, Increased bacterial adherence to respiratory and buccal epithelial cells in protein-energy malnutrition, Immunol. Infect. Dis. 1: 55–57.

    Google Scholar 

  • Chandra, R. K., and Kutty, K. M., 1980, Immunocompetence in obesity, Acta Paediatr. Scand. 69: 25–30.

    Article  CAS  Google Scholar 

  • Chandra, R. K., and Saraya, A. K., 1975, Impaired immunocompetence associated with iron deficiency, J. Pediatr. 86: 899–902.

    Article  CAS  Google Scholar 

  • Chandra, R. K. Seth, V., Bhujavala, and Ghai, O. P., 1977a, Polymorphonuclear leukocyte function in malnourished Indian children, in: Malnutrition and the Immune Response (R. M. Suskind, ed.), Raven Press, New York, pp. 259–264.

    Google Scholar 

  • Chandra, R. K., Ali, S. K., and Chandra, S., 1977b, Thymus-dependent lymphocytes and delayed hypersensitivity in the low birthweight infants, Biol. Neonates 31: 15–18.

    Article  CAS  Google Scholar 

  • Chandra, R. K., Au, B., and Heresi, G., 1981, Single nutrient deficiency and cell-mediated immune responses. II. Pyridoxin, Nutr. Res. 1: 101–106.

    Article  CAS  Google Scholar 

  • Chandra, R. K., Gupta, S., and Singh, H., 1982, Inducer and suppressor T cell subsets in protein-energy malnutrition: analysis by monoclonal antibodies, Nutr. Res. 2: 21–26.

    Article  Google Scholar 

  • Chase, H. P., Long, M. A., and Lavin, M. H., 1979, Cystic fibrosis and malnutrition, J. Pediatr. 95: 337–346.

    Article  CAS  Google Scholar 

  • Chlebowski, R. T., 1985, Significance of altered nutritional status in acquired immune deficiency syndrome (AIDS), Nutr. Cancer 7: 85–91.

    Article  CAS  Google Scholar 

  • Daly, J. M., Reynolds, J., Thorn, A., Kinsley, L., Dietrick-Gallagher, M., Shon, J., and Ruggieri, B., 1988, Immune and metabolic effects of arginine in the surgical patient, Ann. Surg. 208(4):512–523.

    Article  CAS  Google Scholar 

  • Douglas, S. D., and Schöpfer, K., 1977, The phagocyte in protein-calorie malnutrition, in: Malnutrition and the Immune Response (R. M. Suskind, ed.), Raven Press, New York, pp. 231–243.

    Google Scholar 

  • Duchateau, J., Delespesce, G., and Vereeske, P., 1981, Influence of oral zinc supplementation on the lymphocyte response to mitogens of normal subjects, Am. J. Clin. Nutr. 34: 88–93.

    CAS  Google Scholar 

  • Edelman, R., Kulapongs, P., Suskind, R. M., and Olson, R. E., 1977, Leukocyte mobilization in Thai children with kwashiorkor, in: Malnutrition and the Immune Response (R. M. Suskind, ed.), Raven Press, New York, pp. 265–269.

    Google Scholar 

  • Fabris, N., Mocchegiani, E., Galli, M., Irato, L., Lazzarin, A., and Moroni, M., 1988, AIDS, zinc deficiency and thymic hormone failure, J. Am. Med. Assoc. 259: 839–840.

    Article  CAS  Google Scholar 

  • Falutz, J., Tsoukas, C., and Gold, P., 1988, Zinc as a cofactor in human immunodeficiency virus-induced immunosuppression, J. Am. Med. Assoc. 259: 2850–2851.

    Article  CAS  Google Scholar 

  • Ferguson, A. G., Lawlor, G. J., Jr., Neumann, C. G., Oli, W., and Stiehm, E. R., 1974, Decreased rosette-forming lymphocytes in malnutrition and intrauterine growth retardation, J. Pediatr. 85: 717–723.

    Article  CAS  Google Scholar 

  • Flynn, A., 1985, In vitro levels of copper, magnesium and zinc required for mitogen stimulated T lymphocyte proliferation, Nutr. Res. 5: 487–495.

    Article  CAS  Google Scholar 

  • Flynn, A., Loftus, M. A., and Finke, J. H., 1984, Production of interleukin-1 and interleukin-2 in allogeneic mixed lymphocyte cultures under copper, magnesium and zinc deficient conditions, Nutr. Res. 4: 673–679.

    Article  CAS  Google Scholar 

  • Ford, G. W., Jakeman, M., José, D. G., Vorbach, E. A., and Kirke, D. K., 1975, Migration inhibitory factor production by lymphoid cells of Australian aboriginal children with moderate protein-energy malnutrition, Aust. Paediatr. J. 11: 160–164.

    CAS  Google Scholar 

  • Fraker, P. J., Gershwin, M. E., Good, R. A., and Prasad, A., 1986, Interrelationships between zinc and immune function, Fed. Proc. 45: 1474–1479.

    CAS  Google Scholar 

  • Galan, P., Thibault, H., Preziosi, P., and Hercberg, S., 1992, Interleukin-2 production in iron-deficient children, Biol. Trace Elem. Res. 32: 421–426.

    Article  CAS  Google Scholar 

  • Gershwin, M. E., Beach, R. S., and Hurley, L. S. (eds.), 1985, Nutrition and Immunity, Academic Press, New York, pp. 228–258.

    Google Scholar 

  • Gillis, S., Kozak, R., Durante, M., and Weksler, M., 1981, Immunological studies of aging: Decreased production and response to T cell growth factor by lymphocytes from aged humans, J. Clin. Invest. 67: 937–942.

    Article  CAS  Google Scholar 

  • Goldschmidt, M. C., Masin, W. J., Brown, L. R., and Wyde, P. W., 1988, The effect of ascorbic acid deficiency on leukocyte phagocytosis and killing of Actinomyces viscosus, Int. J. Vit. Nutr. Res. 58: 326–334.

    CAS  Google Scholar 

  • Gomez, F., Galvan, R. R., Craviato, J., and Frank, S., 1955, Malnutrition to infancy and childhood with special reference to kwashiorkor, Adv. Pediatr. 7: 131–139.

    CAS  Google Scholar 

  • Goodwin, J. S., and Garry, P. J., 1983, Relationship between megadose vitamin supplementation and immunological functions in a healthy elderly population, Clin. Exp. Immunol. 51: 647–653.

    CAS  Google Scholar 

  • Gordon, J. E., and Scrimshaw, N. S., 1970, Infectious disease in the malnourished child, Med. Clin. North Am. 54: 1495–1508.

    CAS  Google Scholar 

  • Grosh-Worner, L, Grosse-Wilde, H., Bender, G., and Shafer, K. H., 1984, Lymphocyte function in children with iron deficiency, Klin. Wochenschr. 62(22): 1091–1093.

    Article  Google Scholar 

  • Gross, R. L., Reid, J. V. O., Newberne, P. M., Burgess, B., Marston, R., and Hift, M. W., 1975, Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency, Am. J. Clin. Nutr. 28: 225–232.

    CAS  Google Scholar 

  • Harland, P. S. E. G., 1965, Tuberculin reactions in malnourished children, Lancet 2: 719–721.

    Article  CAS  Google Scholar 

  • Helyar, L., and Sherman, A. R., 1987, Iron deficiency and interleukin-1 production by rat leucocyte, Am. J. Clin. Nutr. 46: 346–352.

    CAS  Google Scholar 

  • Heresi, G., and Chandra, R. K., 1980, Effects of severe calorie restriction on thymic factor activity and lymphocyte stimulation response in rats, J. Nutr. 110: 1888–1893.

    CAS  Google Scholar 

  • Heresi, G. P., Saitua, M. T., Pharom, D., and Schlesinger, L., 1981, Leukocyte migration inhibition factor production in marasmic infants, Am. J. Clin. Nutr. 34: 909–913.

    CAS  Google Scholar 

  • Histrinuma, K., Nishimura, T., Hashimoto, Y., and Kimura, S., 1985, Effect of restriction on the immune function of C3H/He mice, Proc. XIIIth Int. Congr. Nutr., Brighton, p. 78.

    Google Scholar 

  • Hwang, D., 1989, Essential fatty acids and immune response, FASEB J. 3: 2052–2056.

    CAS  Google Scholar 

  • Jackson, C.M., 1925, The Effects of Inanition and Malnutrition upon Growth and Structure, McGraw-Hill (Blakiston), New York, p. 285.

    Book  Google Scholar 

  • Jagardeesan, V., and Reddy, V., 1983, Complement system in iron deficiency anemia, Experientia 39: 146.

    Article  Google Scholar 

  • Jambon, B., Ziegler, O., Maire, B., Hulin, M. F., Parent, G., Fall, M., Burnel, D., and Duheille, J., 1988, Thymulin (facteur thymique serique) and zinc contents of the thymus glands of malnourished children, Am. J. Clin. Nutr. 48: 335–442.

    CAS  Google Scholar 

  • Jones, J. D., 1984, Effects of dietary copper depletion on acute and delayed inflammatory responses in mice, Res. Vet. Sci. 37: 205–210.

    CAS  Google Scholar 

  • Kalden, J. R., and Guthry, E. A., 1972, Prolonged skin allograft survival in vitamin C deficient guinea pigs, Eur. Surg. Res. 4: 114–119.

    Article  CAS  Google Scholar 

  • Karpel, J. T., and Peden, V. H., 1972, Copper deficiency in longterm parenteral nutrition, J. Pediatr. 80: 32–36.

    Article  CAS  Google Scholar 

  • Kauffman, C. A., Jones, P. G., and Klorges, M. J., 1986, Fever and malnutrition: Endogenous pyrogen/ interleukin-1 in malnourished patients, Am. J. Clin. Nutr. 44: 449–452.

    CAS  Google Scholar 

  • Kay, N. E., Hollowsy, D. E., Hutton, S. W. Bones, N. D., and Duane, W. C., 1982, Human T-cell functions in experimental ascorbic acid deficiency and spontaneous scurvy, Am. J. Clin. Nutr. 36: 127–130.

    CAS  Google Scholar 

  • Kelley, J. P., and Parker, C. W., 1979, Effects of arachidonic acid and other unsaturated fatty acids on mitogenesis in human lymphocytes, J. Immunol. 122: 1556–1562.

    Google Scholar 

  • Kelley, D. S., Branck, B. L., Love, E. J., Taylor, P. C., Revera, Y. M., and Jacons, J. M., 1991, Dietary α-linolenic acid and immunocompetence in humans, Am. J. Clin. Nutr. 53: 40–46.

    CAS  Google Scholar 

  • Kemahli, A. S., Babacan, E., and Cavdar, A. O., 1988, Cell-mediated immune responses in children with iron deficiency and combined zinc deficiency, Nutr. Res. 8: 129–136.

    Article  Google Scholar 

  • Kielmann, A. A., and McCord, 1978, Weight-for-age as an index of risk of death in children, Lancet 1: 1247–1250.

    Article  CAS  Google Scholar 

  • Kielmann, A. A., Uberoi, I. V., Chandra, R. K., and Vehra, V. L., 1976, The nutritional status on immune capacity and immune responses in preschool children in a rural community in India, Bull. WHO 54: 477–483.

    CAS  Google Scholar 

  • Kiremidjian-Schumacher, L., and Stotzky, G., 1987, Selenium and immune responses, Environ. Res. 42: 277–303.

    Article  CAS  Google Scholar 

  • Kochanowski, B. A., and Sherman, A. R., 1985, Decreased antibody formation in iron-deficient rat pups— Effect of iron repletion, Am. J. Nutr. 41: 271–284.

    Google Scholar 

  • Koller, L. D., Mulhern, S.A., and Frankel, P. C., 1987, Immune dysfunction in rats fed a diet deficient in copper, Am. J. Clin. Nutr. 45: 997–1006.

    CAS  Google Scholar 

  • Koller, L. D., Mulhern, S. A., and Frankel, P. C., 1987, Immune dysfunction in rats fed a diet deficient in copper, Am. J. Clin. Nutr. 45: 997–1006.

    CAS  Google Scholar 

  • Korte, J. J., and Prohaska, J. R., 1987, Dietary copper deficiency alters protein and lipid composition of murine lymphocyte plasma membranes, J. Nutr. 117: 1076–1084.

    CAS  Google Scholar 

  • Krantman, H. J., Young, S. R., Ank, B. J., et al., 1982, Immune function in pure iron deficiency, Am. J. Dis. Child. 136: 840–844.

    CAS  Google Scholar 

  • Krishman, S., Bhyan, U. N., Talwar, G. P., and Ramalingaswani, V., 1974, Effect of vitamin A and protein-calorie undernutrition on immune response, Immunology 27: 383–392.

    Google Scholar 

  • Kulapongs, P., Suskind, R. M., Vithayasai, V., and Olson, E. D., 1977, In vitro cell-mediated immune response in Thai children with protein-calorie malnutrition, in: Malnutrition and the Immune Response (R. M. Suskind, ed.), Raven Press, New York, pp. 99–104.

    Google Scholar 

  • Kuvibidila, S., and Wade, S., 1987, Macrophage function as studied by the clearance of 125I-labeled polyvinyl pyrolidone in iron-deficient and iron-repleted mice, J. Nutr. 117: 170–176.

    CAS  Google Scholar 

  • Kuvibidila, S., Baliga, B. S., and Suskind, R. M., 1981, Effects of iron deficiency anemia on delayed cutaneous hypersensitivity in mice, Am. J. Clin. Nutr. 34: 2635–2640.

    CAS  Google Scholar 

  • Kuvibidila, S., Baliga, B. S., and Suskind, R. M., 1982, Generation of plaque forming cells in iron deficient anemic mice, Nutr. Rep. Int. 26: 861–871.

    CAS  Google Scholar 

  • Kuvibidila, S., Baliga, B. S., and Suskind, R. M., 1983a, The effects of iron deficiency on cytolytic activity of mice spleen and peritoneal cells against allogenic tumor cells, Am. J. Clin. Nutr. 38: 238–244.

    CAS  Google Scholar 

  • Kuvibidila, S., Nauss, K. M., Baliga, B. S., and Suskind, R. M., 1983b, Impairment of blastogenic response of splenic lymphocytes from iron deficient mice. In vivo repletion, Am. J. Clin. Nutr. 37: 15–25.

    CAS  Google Scholar 

  • Kuvibidila, S., Dardenne, M., Savino, W., and Lepol, F., 1990, Influence of iron deficiency on selected thymus functions in mice: Thymulin biological activity, T cell subsets and thymocyte transformation, Am. J. Clin. Nutr. 51: 228–232.

    CAS  Google Scholar 

  • Kuvibidila, S., Murthy, K. K., and Suskind, R. M., 1992, Alteration of interleukin-2 production in iron deficiency anemia, J. Nutr. Immunol. 1(1):81–92.

    CAS  Google Scholar 

  • Kuvibidila, S., Baliga, B. S., and Murthy, K. K., 1991, Impaired protein kinase C activation as one of the possible mechanisms of reduced lymphocyte proliferation in iron deficiency, Am. J. Clin. Nutr. 54: 944–950.

    CAS  Google Scholar 

  • Lowenstein, F. W., 1982, Nutritional status of the elderly in the United States of America 1971-1974, J. Am. Coll. Nutr. 1: 165–177.

    CAS  Google Scholar 

  • Lukacewycz, O. A., Prohaska, J. R., Meyer, S. G., Schmidtke, J. R., Hatfield, S. M., and Marder, P., 1985, Alterations in lymphocyte subpopulations in copper-deficient mice, Infect. Immun. 48: 644–647.

    Google Scholar 

  • Lutter, C. K., Mora, J. O., Habicht, J. P., et al., 1989, Nutritional supplementation: Effects on child stunting because of diarrhea, Am. J. Clin. Nutr. 50: 1–8.

    CAS  Google Scholar 

  • McCarthy, P. O., Johnson, A. A., Walters, C. S., Owopetu, O., and Cartwright, J., 1983, Iron deficiency and immune response in the elderly, Fed. Proc. 42: 1307 (Abstract 5949).

    Google Scholar 

  • Macdougall, L. G., Anderson, R., McNab, G. M., and Katz, J., 1975, The immune response in iron-deficient children: Impaired cellular defense mechanisms with altered humoral components, J. Pediatr. 86: 833–843.

    Article  CAS  Google Scholar 

  • Mackler, B., Pearson, R., Ochs, H., and Finch, C. A., 1984, Iron deficiency in the rat: Effects on neutrophil activation and metabolism, Pediatr. Res. 18: 549–551.

    Article  CAS  Google Scholar 

  • McMurray, D. N., Rey, H., Casazza, L. J., and Watson, R. R., 1977, Effects of moderate malnutrition on concentration of immunoglobulins and enzymes in tears and saliva of young Colombian children, Am. J. Clin. Nutr. 30: 1944–1948.

    CAS  Google Scholar 

  • McMurray, D. N., Loomis, S. A., Casazza, L. J., Rey, H., and Miranda, R., 1981a, Development of impaired cell-mediated immunity in mild and moderate malnutrition, Am. J. Clin. Nutr. 34: 68–77.

    CAS  Google Scholar 

  • McMurray, D. N., Watson, R. R., and Reyes, M. A., 1981b, Effect of renutrition on humoral and cell-mediated immunity in severely malnourished children, Am. J. Clin. Nutr. 34: 2117–2126.

    CAS  Google Scholar 

  • McMurray, D. N., Yetley, E. A., and Burch, T., 1981c, Effects of malnutrition and BCG vaccination on macrophage activation in guinea pigs, Nutr. Res. 1: 373–384.

    Article  Google Scholar 

  • Majumder, M.S.I., and Ali, A., 1987, Immune response of Peyer’s patch cells in rabbit on low protein, Nutr. Res. 7: 671–675.

    Article  CAS  Google Scholar 

  • Makidonan, T., James, S. J., Inamizu, T., and Chang, M. P., 1984, Immunological basis for susceptibility to infection in the aged, Gerontology 30: 279–289.

    Article  Google Scholar 

  • Mark, D. A., Nauss, K. M., Baliga, B. S., and Suskind, R. M., 1981, Depressed transformation response by splenic lymphocytes from vitamin A deficient rats, Nutr. Res. 1: 489–497.

    Article  CAS  Google Scholar 

  • Mark, D. A., Baliga, B. S., and Suskind, R. M., 1985, Vitamin A deficiency and cellular immune responses: Relocation of competent cells? Proc. XIIIth Int. Congr. Nutr., Brighton, p. 146.

    Google Scholar 

  • Mengheri, E., Bises, G., and Gaetani, S., 1988, Differentiated cell-mediated immune response in zinc-deficiency and in protein malnutrition, Nutr. Res. 8: 801–812.

    Article  CAS  Google Scholar 

  • Mertin, J., and Hughes, D., 1975, Specific inhibitory action of polyunsaturated fatty acids on lymphocyte transformation induced by PHA & PPD, Int. Arch. Allergy Appl. Immunol. 48: 203–210.

    Article  CAS  Google Scholar 

  • Meydani, S. N., Barklund, M. P., Liun, S., et al., 1989, Effect of vitamin E supplementation on immune responsiveness of healthy elderly subjects, FASEB J. 3:A1057 (Abstract 4828).

    Google Scholar 

  • Milton, R. C., Reddy, V., and Naider, A. N., 1987, Mild vitamin A deficiency and childhood morbidity— An Indian experience, Am. J. Clin. Nutr. 46: 827–829.

    CAS  Google Scholar 

  • Moncada, S., Palmer, R. M., and Higgs, E. A., 1989, Biosynthesis of nitric oxide from L-arginine: A pathway for the regulation of cell function and communication, Biochem. Pharmacol. 38: 1709–1715.

    Article  CAS  Google Scholar 

  • Moore, L. L., and Humbert, J. R., 1984, Neutrophil bactericidal dysfunction toward oxidant-sensitive microorganisms during experimental iron deficiency, Pediatr. Res. 18(7):684–689.

    Google Scholar 

  • Moretta, N., Valtorta, N., Chirico, G., Chiara, A., Bozzola, M., DeAmici, M., and Maccario, R., 1991, Lymphocyte subpopulation in preterm infants: High percentage of cells expressing P55 chain of interleukin-2 receptor, Biol. Neonate 59: 213–218.

    Article  CAS  Google Scholar 

  • Mulhern, S. A., and Koller, L. D., 1988, Severe or marginal copper deficiency results in a graded reduction in immune status in mice, J. Nutr. 118: 1041–1047.

    CAS  Google Scholar 

  • Murthy, K. K., Suskind, S.A.L., Venkatesh, V., Edwardo, B. J., and Suskind, R. M., 1986, Decreased T lymphocyte function and interleukin-2 production associated with vitamin A deficiency, 6th Int. Congr. Immunol., p. 86.

    Google Scholar 

  • Nagel, J. E., Chopra, R. K., Chrest, F. J., McCoy, M. T., Schneider, E. L., Holbrook, N. J., and Adler, W. H., 1988, Decreased proliferation, interleukin-2 synthesis, and interleukin-2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors, J. Clin. Invest. 81: 96–102.

    Article  Google Scholar 

  • Nauss, K. M., Phua, C. C., Ambrogi, L., and Newberne, P. M., 1985, Immunological changes during progressive stages of vitamin A deficiency in rat, J. Nutr. 115: 909–918.

    CAS  Google Scholar 

  • Newmann, CG., Lawlor, G. I., Stiehm, E. R., et al., 1975, Immunologic responses in malnourished children, Am. J. Clin. Nutr. 28: 89–104.

    Google Scholar 

  • Newmann, C. G., Stiehm, E. R., Swenseid, M. E., Ferguson, A. C., and Lawlor, G., 1977, Cell-mediated immune response in Ghanian children with protein-calorie malnutrition, in: Malnutrition and the Immune Response (R. M. Suskind, ed.), Raven Press, New York, pp. 77–89.

    Google Scholar 

  • Newmann, C. G., Stiehm, E. R., Zahradnick, J., Newton, C., Weber, H., Swendseid, M. E., Cheny, J. D., and Carney, J. M., 1984, Immune function in intrauterine growth retardation, Nutr. Res. 4: 399–419.

    Article  Google Scholar 

  • Pasantiempo, A. M., Taylor, C. E., and Ross, C. A., 1989, Effects of early stages of vitamin A deficiency on the immune response to Streptococcus pneumoniae SS-III, FASEB J. 3:A663 (Abstract 2537).

    Google Scholar 

  • Pasulka, R. S., Bristrian, B. R., Benotti, P. N., and Blackburn, G. L., 1986, The risks of surgery in obese patients, Ann. Intern. Med. 104: 540–546.

    Article  CAS  Google Scholar 

  • Payan, D. G., Wong, M. Y., Chernow-Rogan, T., et al., 1986, Alterations in human leukocyte function induced by ingestion of eicosapentaenoic acid, J. Clin. Immunol. 6: 402–410.

    Article  CAS  Google Scholar 

  • Payette, H., Rola-Pleozczynski, Gliadirian, P., 1990, Nutritional factors in relation to cellular and regulatory immune variables in a free-living elderly population, Am. J. Clin. Nutr. 52: 927–932.

    CAS  Google Scholar 

  • Pedroni, E., Bianchi, E., Ugazio, A. G., and Burgio, G. R., 1975, Immunodeficiency and steely hair, Lancet 1: 1303–1304.

    Article  CAS  Google Scholar 

  • Petro, T. M., 1985, Effect of reduced dietary protein intake on regulation of murine in vitro polyclonal T lymphocyte mitogenesis, Nutr. Res. 5: 263–276.

    Article  CAS  Google Scholar 

  • Petro, T. M., and Watson, R. R., 1982, Dietary stress and development of resistance to Listeria monocytogenes in mice, J. Nutr. 112: 1498–1505.

    CAS  Google Scholar 

  • Prasad, A. J., 1985, Clinical and biochemical manifestations of zinc deficiency in sickle cell disease, Clin. Chem. 21: 582–587.

    Google Scholar 

  • Prasad, J. S., 1980, Effect of vitamin E supplementation on leukocyte function, Am. J. Clin. Nutr. 33: 606–609.

    CAS  Google Scholar 

  • Rao, D. H., and Naider, A. N., 1977, Nutritional supplementation—Whom does it benefit most? Am. J. Clin. Nutr. 30: 1612–1616.

    CAS  Google Scholar 

  • Reddy, V., Jagadeesan, V., Ragharamulu, N., Bhaskaran, C., and Srikantia, S. G., 1976, Functional significance of growth retardation in malnutrition, Am. J. Clin. Nutr. 29: 3–7.

    CAS  Google Scholar 

  • Reed, J. D., Redding-Lallinger, R., and Orringer, E. P., 1987, Nutrition and sickle cell disease, Am. J. Hematol. 24: 441–455.

    Article  CAS  Google Scholar 

  • Reynolds, J. V., Daly, J. M., Zhang, S., et al., 1988, Immunomodulatory mechanisms of arginine, Surgery 104: 142–151.

    CAS  Google Scholar 

  • Rickard, K. A., Grosfeld, J. L., Kirksey, A., Ballantine, T.V.N., and Baehner, R. L., 1979, Reversal of protein-energy malnutrition in children during treatment of advanced neoplastic diseases, Ann. Surg. 190: 771–781.

    Article  CAS  Google Scholar 

  • Rivera, J., Habicht, J. P., Torres, N., et al., 1986, Decreased cellular immune response in wasted but not in stunted children, Nutr. Res. 6: 1161–1170.

    Article  Google Scholar 

  • Robinson, M. F., Godfrey, P. J., Thomson, C. D., Rea, H. M., and van Rij, M., 1979, Blood selenium and glutathione peroxidase activity in normal subjects and in surgical patients with and without cancer in New Zealand, Am. J. Clin. Nutr. 32: 1477–1485.

    CAS  Google Scholar 

  • Robson, L. C., and Schwarz, M. R., 1975, Vitamin B6 deficiency and the lymphoid system. Effects of vitamin B6 deficiency in utero on the immunological competence of the offspring, Cell. Immunol. 16: 145–156.

    Article  CAS  Google Scholar 

  • Rosa, F. W., and Turshan, M., 1970, Fetal nutrition, Bull. WHO 43: 785–795.

    CAS  Google Scholar 

  • Rossouw, W. J. E., 1989, Kwashiorkor in North America, Am. J. Clin. Nutr. 49: 588–592.

    CAS  Google Scholar 

  • Salimonu, L. S., Johnson, A. O. K., Williams, A. I. O., Iyabo-Adeleye, G., and Osunkoya, B. O., 1982, Lymphocyte populations and antibody levels in immunized malnourished children, Br. J. Nutr. 48: 7–14.

    Article  CAS  Google Scholar 

  • Salonen, J. T., Alfthan, G., Huttunen, J. K., and Puska, P., 1984, Association between serum selenium and the risk of cancer, Am. J. Epidemiol. 120: 342–349.

    CAS  Google Scholar 

  • Satyanarayana, K., Bhaskaram, P., Seshu, V. C., and Reddy, V., 1980, Influence of nutrition on postvaccinal tuberculin sensitivity, Am. J. Clin. Nutr. 33: 2334–2337.

    CAS  Google Scholar 

  • Schlesinger, L., Ohlbanm, A., Greg, L., and Stekel, A., 1976, Decreased interferon production by leukocytes in marasmus, Am. J. Clin. Nutr. 29: 758–761.

    CAS  Google Scholar 

  • Schlesinger, L., Ohlbanm, A., Greg, L., and Stekel, A., 1977, Cell-mediated immune studies in marasmic children from Chile: Delayed hypersensitivity, lymphocyte transformation and interferon production, in: Malnutrition and the Immune Response (R. M. Suskind, ed.), Raven Press, New York, pp. 91–98.

    Google Scholar 

  • Seth, V., and Chandra, R. K., 1972, Opsonic activity, phagocytosis and bactericidal capacity of polymorphs in undernutrition, Arch. Dis. Child. 47: 282–284.

    Article  CAS  Google Scholar 

  • Sellmeyer, E., Bhettay, E., Truswell, A. S., Meyers, O. L., and Hansen, J. D. L., 1972, Lymphocyte transformation in malnourished children, Arch. Dis. Child. 47: 429–435.

    Article  CAS  Google Scholar 

  • Sherman, A. R., and Lockwood, J. F., 1987, Impaired natural killer cell activity in iron-deficient rat pups, J. Nutr. 117: 567–571.

    CAS  Google Scholar 

  • Sirinsinha, S., Suskind, R. M., Edelman, R., Charupatana, C., and Olson, R. E., 1973, Complement and C3 proactivator levels in children with protein-calorie malnutrition and effect of dietary treatment, Lancet 1: 1016–1020.

    Article  Google Scholar 

  • Sirinsinha, S., Suskind, R. M., Edelman, R., Asvapaka, C., and Olson, R. E., 1977, Secretory IgA in Thai children with protein-calorie malnutrition, in: Malnutrition and the Immune Response (R. M. Suskind, ed.), Raven Press, New York, pp. 195–199.

    Google Scholar 

  • Smith, I. F., Latham, M. C., Azubnike, J. A., Butler, W. R., Phillips, L. S., Pond, W. G., and Enwonwu, C. O., 1981, Blood plasma levels of cortisol, insulin, growth hormone and somatomedin in children with marasmus, kwashiorkor, and intermediate forms of protein-energy malnutrition, Proc. Soc. Exp. Biol. Med. 167: 607–611.

    Article  CAS  Google Scholar 

  • Sullivan, J. L., and Ochs, H. D., 1978, Copper deficiency and the immune system, Lancet 2: 686.

    Article  CAS  Google Scholar 

  • Suskind, D., Murthy, K. K., and Suskind, R. M., 1990, The malnourished child: An overview, in: The Malnourished Child, Nestle Nutrition Workshop Series, Vol. 19 (R. M. Suskind and L. Lewinter-Suskind, eds.), Nestec Ltd., Vevey/Raven Press, New York, pp. 1–22.

    Google Scholar 

  • Suskind, R. M., Thanangkul, O., Damongsak, D., Leitzmann, C., Suskind, L., and Olson, E., 1977, The malnourished child: Clinical, biochemical, and hematologic changes, in: Malnutrition and the Immune Response (R. M. Suskind, ed.), Raven Press, New York, pp. 1–8.

    Google Scholar 

  • Tapazoglou, E., Prasad, A. S., Hill, G., Brewer, G. J., and Kaplan, J., 1985, Decreased natural killer cell activity in patients with zinc deficiency and sickle cell disease, J. Lab. Clin. Med. 15: 19–22.

    Google Scholar 

  • Thurnham, D. I., 1989, Vitamin A deficiency and its role in infection, Trans. R. Soc. Trop. Med. Hyg. 83: 721–723.

    Article  CAS  Google Scholar 

  • Underwood, E. J., 1971, Copper, in: Trace Elements in Humans and Animal Nutrition, 3rd ed., Academic Press, New York, p. 57.

    Google Scholar 

  • Vanderpas, J. B., Contempré, B., Duale, N. L., Goossens, W., Bebe, N., Thorpe, R., Ntambue, K., Dumont, J., Thilly, C. H., and Diplock, A. T., 1990, Iodine and selenium deficiency associated with cretinism in northern Zaire, Am. J. Clin. Nutr. 52: 1087–1093.

    CAS  Google Scholar 

  • Victora, C. G., Barros, F. C., Kirkwood, B. R., and Vaughan, J. P., 199, Pneumonia, diarrhea, and growth in the first 4 years of life: A longitudinal study of 5914 urban Brazilian children, Am. J. Clin. Nutr. 52: 391-396.

    Google Scholar 

  • Vitale, J. J., and Broitman, S. A., 1981, Lipids and immune function, Cancer Res. 41: 3706–3710.

    CAS  Google Scholar 

  • Vyas, D., and Chandra, R. K., 1983, Thymic factor activity, lymphocyte stimulation response and antibody producing cells in copper deficiency, Nutr. Res. 3: 343–349.

    Article  CAS  Google Scholar 

  • Walker, A. R. P., and Walker, B. F., 1990, Functional significance of mild-moderate malnutrition, Am. J. Clin. Nutr. 52: 178–179.

    CAS  Google Scholar 

  • Walter, T. Arrendoch, S., Avenato, M., and Stekel, A., 1986, Effects of iron therapy on phagocytosis and bactericidal activity in neutrophils or iron deficient infants, Am. J. Clin. Nutr. 44: 877–882.

    CAS  Google Scholar 

  • Waterlow, J. C., 1972, Classification and deficiency of protein-energy malnutrition, Br. Med. J. 2: 566–609.

    Article  Google Scholar 

  • Whittle, H. C., Mee, J., Weberlinska, J., Yalsubu, A., Onuora, C., and Gomwalk, N., 1980, Immunity to measles in malnourished children, Clin. Exp. Immunol. 42: 144–151.

    CAS  Google Scholar 

  • Woodward, B.D., and Miller, R. G., 1991, Depression of thymus-dependent immunity in wasting protein-energy malnutrition does not depend on an altered ratio of helper (CD4 +) to suppressor (CD8 +) T cells or on a disproportionately large atrophy of the T-cell relative to the B-cell pool, Am. J. Clin. Nutr. 53: 1329–1335.

    CAS  Google Scholar 

  • Yearick, E. S., Wang, M. S., and Pisias, S., 1980, Nutritional status of the elderly: Dietary and biochemical findings, J. Gerontol. 35: 663–671.

    Article  CAS  Google Scholar 

  • Yoshikawa, T. T., 1984, Aging and infectious diseases: State of the art, Gerontology 30: 275–278.

    Article  CAS  Google Scholar 

  • Ziegler, H. D., and Ziegler, P. B., 1975, Depression of tuberculin reaction in mild and moderate-protein-calorie malnourished children following BCG vaccination, Johns Hopkins Med. J. 137: 59–64.

    CAS  Google Scholar 

  • Zile, M. H., and Cullum, M. E., 1983, The functions of vitamin A: Current concepts, Proc. Soc. Exp. Biol. Med. 172: 139–152.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media New York

About this chapter

Cite this chapter

Kuvibidila, S., Yu, L., Ode, D., Warrier, R.P. (1993). The Immune Response in Protein-Energy Malnutrition and Single Nutrient Deficiencies. In: Klurfeld, D.M. (eds) Nutrition and Immunology. Human Nutrition. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2900-2_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2900-2_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6257-9

  • Online ISBN: 978-1-4615-2900-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics