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Abstract

Poxviruses are DNA-containing viruses that infect both vertebrate and invertebrate hosts. Smallpox, caused by an orthopoxvirus, was a major scourge to humanity for centuries. Vaccination against smallpox was introduced by Jenner in 1798 and by means of this method it was eventually possible to eradicate this disease over a decade ago.1 Vaccinia viruses (VV) are the most frequently studied members of the orthopoxvirus group. Recently, the entire genome of the Copenhagen strain of VV was sequenced because it is recognized that these viruses have the potential of being used as live recombinant expression vectors for molecular studies as well as for developing new vaccines.2 Studies with VV have resulted in several novel findings which not only have contributed to the field of virology, but have also enriched our understanding of important eukaryotic processes. The RNA polymerase,3,4 the poly(A) polymerase,5,6 and the 5′ cap of messenger RNAs (mRNAs)7 were all reported in studies with VV about the same time or before they were recognized in eukaryotic cells.

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Bablanian, R. (1993). Translational Regulation by Vaccinia Virus. In: Ilan, J. (eds) Translational Regulation of Gene Expression 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2894-4_9

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  • DOI: https://doi.org/10.1007/978-1-4615-2894-4_9

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