Protease Inhibitors and Pancreatic Carcinogenesis

  • B. D. Roebuck
  • Daniel S. Longnecker


In the United States, pancreatic cancer is the fifth most common cause of death due to cancer, claiming over 25,000 lives annually (Silverberg and Lubera, 1989). Males are at a slightly higher risk than females (1.5:1) and for both sexes, the age-adjusted death rates have shown a steady increase from 1930 to 1970. Usually, diagnosis of pancreatic cancer is late in the course of disease development, thus precluding effective treatment. The mean survival following diagnosis is 4 to 6 months and the 5-year survival rate is one of the worst of any cancer being less than 5% of cases (Mack, 1982).


Pancreatic Cancer Acinar Cell Trypsin Inhibitor Syrian Golden Hamster Pancreatic Carcinogenesis 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • B. D. Roebuck
    • 1
  • Daniel S. Longnecker
    • 2
  1. 1.Department of Pharmacology and Toxicology Dartmouth Medical SchoolHanoverUSA
  2. 2.Department of PathologyDartmouth Medical SchoolHanoverUSA

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