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Suppression of c-myc by Anticarcinogenic Protease Inhibitors

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Protease Inhibitors as Cancer Chemopreventive Agents

Abstract

Malignant transformation in vitro and in vivo can be prevented by treating carcinogen-exposed cells or animals with a variety of microbial and plant protease inhibitors. As one approach to studying the nature by which protease inhibitors may be preventing malignant transformation, we have performed studies on the effects of protease inhibitors on c-myc expression in proliferating normal and transformed mouse fibroblast cells. Our experiments were designed with the aim of understanding the way in which protease inhibitors might be working in the cell to prevent malignant transformation and determining whether the protease inhibitor effect of reducing transformation yields could be related to the reduction in c-myc RNA levels by protease inhibitors. Additional experiments were also performed, examining the role of c-myc in the cell cycle and determining the effect of antipain on the stability of the c-myc message.

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Authors and Affiliations

  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Janice D. Chang

  2. Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Ann R. Kennedy

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  1. Janice D. Chang
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  2. Ann R. Kennedy
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Editors and Affiliations

  1. Department of Environmental Medicine, New York University Medical Center, New York, New York, 10016, USA

    Walter Troll

  2. Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Ann R. Kennedy

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Chang, J.D., Kennedy, A.R. (1993). Suppression of c-myc by Anticarcinogenic Protease Inhibitors. In: Troll, W., Kennedy, A.R. (eds) Protease Inhibitors as Cancer Chemopreventive Agents. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2882-1_16

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  • DOI: https://doi.org/10.1007/978-1-4615-2882-1_16

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