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Cell Membrane Enzymes Containing Chymotrypsin-like Activity

  • Jonathan Yavelow
  • Lorraine T. Schepis
  • Joseph NickelsJr.
  • George Ritchie

Abstract

The study of protease inhibitors and carcinogenesis has aided in the identification of proteolytic enzymes in the regulation of cell growth, invasion, and metastasis. Since the early 1970s the value of protease inhibitors in the suppression of tumorigenesis has been demonstrated in a variety of tumors (Troll et al., 1970; Hozumi et al., 1972; Weed et al., 1985). The proteases, namely, plasminogen activator, plasmin, collagenase (Mignatti et al., 1986), and cathepsin D (Sloane et al., 1986), are primarily appreciated for their role in invasion and metastasis. However, Corasanti et al. (1982) have demonstrated that ε-aminocaproic acid suppresses dimethylhydrazine-induced colon tumors in mice, implicating a possible role for plasminogen activator in the mechanism of carcinogenesis. The control of intracellular protein turnover (Waxman et al., 1985; Hershko, 1988), the maturation of polypeptide precursors (Bathurst et al., 1987), the regulation of neutrophil activation (King et al., 1987), and the control of sister chromatid exchange (Kennedy et al., 1984) are several examples where proteases have been directly or indirectly implicated in cellular regulation.

Keywords

Fluorescence Anisotropy Human Amniotic Membrane Chymotrypsin Inhibitor Membrane Protease Cell Membrane Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Jonathan Yavelow
    • 1
  • Lorraine T. Schepis
    • 2
  • Joseph NickelsJr.
    • 3
  • George Ritchie
    • 4
  1. 1.Department of BiologyRider CollegeLawrencevilleUSA
  2. 2.Department of Molecular BiologyPrinceton UniversityPrincetonUSA
  3. 3.Department of Microbiology and Molecular GeneticsRutgers UniversityNew BrunswickUSA
  4. 4.Department of PhysicsRider CollegeNew BrunswickUSA

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