Abstract
It is more difficult to measure blood flow to the skeleton than to any other organ or tissue in the body because of the complex arterial supply and venous drainage of each bone and the heterogeneity of cortical and trabecular bone and bone marrow. Most techniques are invasive and some are lethal, so that they cannot be applied to human studies. On the other hand, animal experiments can give an insight into the metabolism and growth of bone and such topics as fracture healing. The methods to be considered here are (1) indicator fractionation, using radioactive microspheres, (2) the clearance of bone-seeking tracers, (3) the washout of diffusible tracers and (4) laser Doppler measurements. The methods are the same in principle as those used for other organs or tissues, but the skeleton does pose particular problems.
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© 1993 Plenum Press, New York
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Tothill, P. (1993). Measurement of Bone Blood Flow in Animals. In: Schoutens, A., Arlet, J., Gardeniers, J.W.M., Hughes, S.P.F. (eds) Bone Circulation and Vascularization in Normal and Pathological Conditions. NATO ASI Series, vol 247. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2838-8_9
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DOI: https://doi.org/10.1007/978-1-4615-2838-8_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-44523-1
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