Abstract
The microvasculature of bone plays a crucial role in skeletal ontogeny, remodelling, and repair, and is involved in most pathological states in bone marrow. The review suggested here summarizes recent reports on interactions between the intraosseous vascular system and the processes of osteogenesis and myelopoisis. Emphasis will be placed on the actived biological role of vascular endothelium and on a growing appreciation in the literature that autonomic and sensory nerves play an integrating role in both vascular and cellular functions in bone.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baglin, T.P., J. Crocker, A. Timmins, S. Chandler, B.J. Boughton: Bone marrow hypervascularity in patients with myelofibrosis identified by infra-red thermography. Clin. Lab. Haemat. 13: 341–348 (1991).
Bjurholm, A.: Neuroendocrine peptides in bone. Thesis. ISBN 91-7900-875-5, Stockholm 1989.
Brighton, C.T., R.M. Hunt: Early histological and ultrastructural changes in medullary fracture callus. J. Bone Joint Surg. 73A: 832–847 (1991).
Brinker, M.R., H.L. Lippton, S.D. Cook, A.L. Hyman: Pharmacological regulation of the circulation of bone. J. Bone Joint Surg. 72A: 964–975 (1990).
Broxmeyer, H.E., D.E. Williams: The production of myeloid blood cells and their regulation during health and disease. Crit. Rev. Oncol. Hematol. 8: 173–226 (1988).
Bünger, C. Hemodynamics of the juvenile knee. Joint effusion and synovial inflammation studied in dogs. Acta Orthop. Scand. 58(suppl 222): 1–104 (1987).
Burkhardt, B., R. Bartl, B. Frisch, K. Jäger, C. Mahl, W. Hill, G. Kettner: The structural relationship of bone forming and endothelial cells of the bone marrow. In: Arlet J, Ficat RP, Hungerford DS (eds): Bone circulation, pp 2–14. Williams and Wilkins, Baltimore 1984.
Burkhardt, B., G. Kettner, W. Böhm, M. Schmidmeier, R. Schlag, B. Frisch, B. Mailman, W. Eisenmenger, T.H. Gilg: Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone 8: 157–164 (1987).
Canalis, E., J. Lorenzo, W.H. Burgess, T. Maciag: Effects of endothelial cell growth factor on bone remodelling in vitro. J. Clin. Invest. 79: 52–58 (1987).
Caplan, A.I.: Mesenchymal stem cells. J. Orthop. Res. 9: 641–650 (1991).
Carrington, J.L., A.H. Reddi: Parallels between development of embryonic and matrix-induced endochondral bone. Bioessays 13: 403–408 (1991).
Chen, L.T., M.F. Chen, V.L. Porter: Increased bone marrow blood flow in rabbits with acute hemolytic anemia. Am. J. Hematol. 22: 35–41 (1986).
Davis, R.F., L.C. Jones, D.S. Hungerford: The effect of sympathectomy on blood flow in bone. Regional distribution and effect over time. J. Bone Joint Surg. 69: 1384–1390 (1987).
Davis, T.R, M.B. Wood: Endothelial control of long bone vascular resistance. J. Orthop. Res. 10: 344–349 (1992).
Dean, M.T., M.B. Wood, P.M. Vanhoutte: Antagonist drugs and bone vascular smooth muscle. J. Orthop. Res. 10: 104–111 (1992).
De Simone, D.P., A.H. Reddi: Vascularization and endochondral bone development: Changes in plasminogen activator activity. J. Orthop. Res. 10: 320–324 (1992).
Draenert, K., Y. Draenert: The vascular system of bone marrow. Scanning Electron Microscopy IV: 113–122 (1980).
Floyd, W.E., D.J. Zaleske, A.L. Schiller, C. Trahan, H.J. Mankin: Vascular events associated with the appearance of the secondary center of ossification in the murine distal femoral epiphysis. J. Bone Joint Surg. 69A: 185–190 (1987).
Folkman, J.: Toward an understanding of angiogenesis: search and discovery. Perspectives in Biology and Medicine 29: 10–36 (1985).
Ganey, T.M., S.M. Love, J.A. Ogden: Development of vascularization in the chondroepiphysis of the rabbit. J. Orthop. Res. 10: 496–510 (1992).
Guenther H.L., H. Fleisch, N. Sorgente: Endothelial cells in culture synthesize a potent bone cell active mitogen. Endocrinology 119: 193–201 (1986).
Hansen, E.S., K. Soballe, T.B. Henriksen, V.E. Hjortdal, C. Biinger: 99mTc-diophosphonate uptake and hemodynamics in arthritis of the immature dog knee. J. Orthop. Res. 9: 191–202 (1991).
Hill, E.L., R. Elde: Distribution of CGRP-0, VIP-, D beta H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat. Cell Tissue Res. 264: 469–480 (1991).
Hohmann, E.X., L. Levine, A.H. Tashjian Jr: Vasoactive intestinal peptide stimulates bone resorption via a cyclic adenosine 3′5′ monophosphate dependent mechanism. Endocrinology 112: 1233–1239 (1983).
Hulth, A., O. Johnell, L. Lindberg: Demonstration of blood-vessellike structures in cartilaginous callus by antilaminin and antiheparin sulphate proteoglycan antibodies. Clin. Orthop. 254: 289–293 (1990).
Hunter, W.L., A.L. Arsenault: Endothelial cell division in metaphyseal capillaries during endochondral bone formation in rats. Anat. Rec. 227: 351–358 (1990).
Hunter, W.L., A.L. Arsenault, A.B. Hodsman: Rearrangement of the metaphyseal vasculature of the rat growth plate in rickets and rachitic reversal: a model of vascular arrest and angiogenesis renewed. Anat. Rec. 229: 453–461 (1991).
Iversen, P.O., G. Nicholaysen, H.B. Benestad: Blood flow to bone marrow during development of anemia or polycythemia in the rat. Blood 79: 594–601 (1992).
Jones, A.R., C.C. Clark, C.T. Brighton: The effects of rat microvascular cell products on cultured rat calvarial bone cells. Trans. Orthop. Res. Soc. 17: 188 (1992).
Jurvelin, J., T. Lahtinen, I. Kiviranta, I. Arnala, R. Lappalainen, M. Tammi, H.J. Helminen: Blood flow, histomorphology, and elemental composition of the canine femur after physical training or immobilization. Acta Physiol. Scand. 132: 385–389 (1988).
Kelly, P.J., J.T. Bronk: Venous pressure and bone formation. Microvasc. Res. 39: 364–375 (1990).
Klagsbrun, M., S. Smith: Purification of a cartilage-derived growth factor. J. Biol. Chem. 255: 10859–10866 (1980).
Lahtinen, R., T. Lahtinen, T. Romppanen: Bone and bone-marrow blood flow in chronic granulocytic leukemia and primary myelofibrosis. J. Nucl. Med. 23: 218–224 (1982).
Laroche, M., C. Ribot, J.L. Puech, J.M. Pouilles, J. Arlet, H. Boccalon, P. Puel, B. Mazieres: Arteriopathy of the lower limbs and osteoporosis in men. Ass. Res. Circ. Osseous News Letter 4: 30–36 (1992).
Lindblad, B.E., L.B. Nielsen, A. Bjurholm, E.S. Hansen: Vasoconstrictive action of neuropeptide Y in bone. Trans. Orthop. Res. Soc. 18 (1993).
Lucas, P.D.: Reversible reduction in bone blood flow in streptozotocin-diabetic rats. Experientia 43: 894–895 (1987).
Lundgaard, A., C. Aalkjœr, M.J. Mulvany, A. Bjurholm, E.S. Hansen: Effects of calcitonin gene-related peptide and vasoactive intestinal peptide on resistance vessels isolated from cancellous bone. Trans. Orthop. Res. Soc. 18 (1993).
Macintyre, I., M. Zaidi, A.S. Alam, H.K. Datta, B.S. Moonga, P.S. Lidbury, M. Hecker, J.R. Vane: Osteoclastic inhibition — an action of nitric oxide not mediated by cyclic GMP. Proc. Natl. Acad. Sci. USA 88: 2936–2940 (1991).
Martiat, P., A. Ferrant, M. Cogneau, A. Bol, C. Michel, J. Rodhain, J.L. Michaux, G. Sokal: Assessment of bone marrow blood flow using positron emission tomography: no relationship with bone marrow cellularity. Br. J. Haematol 66: 307–310 (1987).
Mathiassen, B., S. Nielsen, J.S. Johansen, D. Hartwell, J. Ditzel, P. Rodbro, C. Christiansen: Long-term bone loss in insulin-dependent diabetic patients with microvascular complications. J. Diabet. Complic. 4: 145–149 (1990).
McCarthy, I.D., Y. Lang: The relationship between bone blood flow, strontium clearance, and bone turnover in the tibial cortex. Trans. Orthop. Res. Soc. 17: 11 (1992).
McClugage, S.J., R.S. McCuskey: Relationship of the microvascular system to bone resorption and growth in situ. Microvasc. Res. 6: 132–134 (1973).
McInnis, J.C., R.A. Robb, P.J. Kelly: The relationship of bone blood flow, bone tracer deposition, and endosteal new bone formation. J. Lab. Clin. Med. 96: 511–522 (1980).
McKinstry, P., J.E. Schnitzer, T. Light, J.A. Ogden, P. Hoffer: Relationship of 99mTc-MDP uptake to regional osseous circulation in skeletal immature and mature dogs. Skeletal Radiol. 8: 115–121 (1982).
Monroy, R.L., T.A. Davis, T.B. Nielsen, A.J. Staton: Peripheral blood hematopoietic progenitor/stem cells proliferate to form colonies in liquid culture but require contact with vascular endothelial cells and GM-CSF. Int. J. Cell Cloning 10: 105–115 (1992).
Moses, M.A., J. Sudhalter, R. Langer: Identification of an inhibitor of neovascularization from cartilage. Science 248: 1408–1410 (1990).
Nanmark, U., F. Buch, T. Albrechtsson: Influence of direct currents on bone vascular supply. Scand. J. Plast. Reconstr. Surg. 22: 113–115 (1988).
Peius, L.M.: Modulation of myelopoiesis by prostaglandin E2: Demonstration of a novel mechanism of action in vivo. Immunol. Res. 8: 176–184 (1989).
Reddi, A.H., K.E. Kuettner: Vascular invasion of cartilage: correlation of morphology with lysozome, glycosaminoglycans, protease, and protease-inhibitor activity during endochondral bone development. Dev. Biol. 82: 217–223 (1981).
Reeve, J., M. Arlot, R. Wootton, C. Edouard, M. Tellez, R. Hesp, J.R. Green, P.J. Meunier: Skeletal blood flow, iliac histomorphometry, and strontium kinetics in osteoporosis: A relationship between blood flow and corrected apposition rate. J. Endocrin. Metab. 66: 1124–1131 (1988).
Roorda, J., C.S. Han, M.B. Wood: In vivo confirmation of bone blood flow control by endothelial derived relaxation factor in the canine tibia. Trans. Orthop. Res. Soc. 17: 8 (1992).
Schoutens, A., M. Verhas, N. Dourov, P. Bergmann, F. Caulin, A. Verschaeren, M. Mone, A. Heilporn: Bone loss and bone blood flow in paraplegic rats treated with calcitonin, diphosphonate, and indomethacin. Calcif. Tissue Int. 42: 136–143 (1988).
Schoutens, A., M. Verhas, N. Dourov, A. Verschaeren, M. Mone, A. Heilporn: Anemia and marrow blood flow in the rat. Br. J. Haematol. 74: 514–518 (1990).
Semb, H.: Experimental limb disuse and bone blood flow. Acta Orthop. Scand. 40: 552–562 (1969).
Shapiro, I.M., E.E. Golub, B. Chance, C. Piddington, O. Oshima, O.C. Tuncay, J.C. Haselgrove: Linkage between energy status of perivascular cells and mineralization of the chick growth cartilage. Dev. Biol. 129: 372–379 (1988).
Stanka, P., U. Bellack, A. Lindner: On the morphology of the terminal microvasculature during endochondral ossification in rats. Bone Miner. 13: 93–101 (1991).
Streeten, E.A., M.L. Brandi: Biology of bone endothelial cells. Bone Miner. 10: 85–94 (1990).
Thiele, J., V. Rompcik, S. Wagner, R. Fisher: Vascular architecture and collagen type IV in primary myelofibrosis and polycythemia vera: an immunomorphometric study on trephine biopsies of the bone marrow. Br. J. Hematol 80: 227–234 (1992).
Thompson, T.J., P.D. Owens, D.J. Wilson: Intramembranous osteogenesis and angiogenesis in the chick embryo. J. Anat. 166: 55–65 (1989).
Trueta, J.: The role of vessels in osteogenesis. J. Bone Joint Surg 45B: 402–418 (1963).
Wickramasinghe, S.N.: Observations on the ultrastructure of sinusoids and reticular cells in human bone marrow. Clin. Lab. Haemat. 13: 263–278 (1991).
Winet, H., J.Y. Bao, R. Moffat: A control model for tibial cortex neovascularization in the bone chamber. J. Bone Miner. Res. 5: 19–30 (1990).
Zaidi, M., K. Fuller, P.J.R. Bevis, R.E. Gainesdas, T.J. Chambers, I. Maclntyre: Calcitonin Gene-Related Peptide inhibits osteoclastic bone resorption: A comparative study. Calcif. Tiss. Int. 40: 149–154 (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Plenum Press, New York
About this chapter
Cite this chapter
Hansen, E.S. (1993). Microvascularization, Osteogenesis, and Myelopoiesis in Normal and Pathological Conditions. In: Schoutens, A., Arlet, J., Gardeniers, J.W.M., Hughes, S.P.F. (eds) Bone Circulation and Vascularization in Normal and Pathological Conditions. NATO ASI Series, vol 247. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2838-8_4
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2838-8_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-44523-1
Online ISBN: 978-1-4615-2838-8
eBook Packages: Springer Book Archive