Skip to main content

Microvascularization, Osteogenesis, and Myelopoiesis in Normal and Pathological Conditions

  • Chapter
Book cover Bone Circulation and Vascularization in Normal and Pathological Conditions

Part of the book series: NATO ASI Series ((NSSA,volume 247))

Abstract

The microvasculature of bone plays a crucial role in skeletal ontogeny, remodelling, and repair, and is involved in most pathological states in bone marrow. The review suggested here summarizes recent reports on interactions between the intraosseous vascular system and the processes of osteogenesis and myelopoisis. Emphasis will be placed on the actived biological role of vascular endothelium and on a growing appreciation in the literature that autonomic and sensory nerves play an integrating role in both vascular and cellular functions in bone.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baglin, T.P., J. Crocker, A. Timmins, S. Chandler, B.J. Boughton: Bone marrow hypervascularity in patients with myelofibrosis identified by infra-red thermography. Clin. Lab. Haemat. 13: 341–348 (1991).

    Article  CAS  Google Scholar 

  • Bjurholm, A.: Neuroendocrine peptides in bone. Thesis. ISBN 91-7900-875-5, Stockholm 1989.

    Google Scholar 

  • Brighton, C.T., R.M. Hunt: Early histological and ultrastructural changes in medullary fracture callus. J. Bone Joint Surg. 73A: 832–847 (1991).

    Google Scholar 

  • Brinker, M.R., H.L. Lippton, S.D. Cook, A.L. Hyman: Pharmacological regulation of the circulation of bone. J. Bone Joint Surg. 72A: 964–975 (1990).

    Google Scholar 

  • Broxmeyer, H.E., D.E. Williams: The production of myeloid blood cells and their regulation during health and disease. Crit. Rev. Oncol. Hematol. 8: 173–226 (1988).

    Article  PubMed  CAS  Google Scholar 

  • Bünger, C. Hemodynamics of the juvenile knee. Joint effusion and synovial inflammation studied in dogs. Acta Orthop. Scand. 58(suppl 222): 1–104 (1987).

    Google Scholar 

  • Burkhardt, B., R. Bartl, B. Frisch, K. Jäger, C. Mahl, W. Hill, G. Kettner: The structural relationship of bone forming and endothelial cells of the bone marrow. In: Arlet J, Ficat RP, Hungerford DS (eds): Bone circulation, pp 2–14. Williams and Wilkins, Baltimore 1984.

    Google Scholar 

  • Burkhardt, B., G. Kettner, W. Böhm, M. Schmidmeier, R. Schlag, B. Frisch, B. Mailman, W. Eisenmenger, T.H. Gilg: Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone 8: 157–164 (1987).

    Article  PubMed  CAS  Google Scholar 

  • Canalis, E., J. Lorenzo, W.H. Burgess, T. Maciag: Effects of endothelial cell growth factor on bone remodelling in vitro. J. Clin. Invest. 79: 52–58 (1987).

    Article  PubMed  CAS  Google Scholar 

  • Caplan, A.I.: Mesenchymal stem cells. J. Orthop. Res. 9: 641–650 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Carrington, J.L., A.H. Reddi: Parallels between development of embryonic and matrix-induced endochondral bone. Bioessays 13: 403–408 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Chen, L.T., M.F. Chen, V.L. Porter: Increased bone marrow blood flow in rabbits with acute hemolytic anemia. Am. J. Hematol. 22: 35–41 (1986).

    Article  PubMed  CAS  Google Scholar 

  • Davis, R.F., L.C. Jones, D.S. Hungerford: The effect of sympathectomy on blood flow in bone. Regional distribution and effect over time. J. Bone Joint Surg. 69: 1384–1390 (1987).

    PubMed  CAS  Google Scholar 

  • Davis, T.R, M.B. Wood: Endothelial control of long bone vascular resistance. J. Orthop. Res. 10: 344–349 (1992).

    Article  PubMed  CAS  Google Scholar 

  • Dean, M.T., M.B. Wood, P.M. Vanhoutte: Antagonist drugs and bone vascular smooth muscle. J. Orthop. Res. 10: 104–111 (1992).

    Article  PubMed  CAS  Google Scholar 

  • De Simone, D.P., A.H. Reddi: Vascularization and endochondral bone development: Changes in plasminogen activator activity. J. Orthop. Res. 10: 320–324 (1992).

    Article  Google Scholar 

  • Draenert, K., Y. Draenert: The vascular system of bone marrow. Scanning Electron Microscopy IV: 113–122 (1980).

    Google Scholar 

  • Floyd, W.E., D.J. Zaleske, A.L. Schiller, C. Trahan, H.J. Mankin: Vascular events associated with the appearance of the secondary center of ossification in the murine distal femoral epiphysis. J. Bone Joint Surg. 69A: 185–190 (1987).

    Google Scholar 

  • Folkman, J.: Toward an understanding of angiogenesis: search and discovery. Perspectives in Biology and Medicine 29: 10–36 (1985).

    PubMed  CAS  Google Scholar 

  • Ganey, T.M., S.M. Love, J.A. Ogden: Development of vascularization in the chondroepiphysis of the rabbit. J. Orthop. Res. 10: 496–510 (1992).

    Article  PubMed  CAS  Google Scholar 

  • Guenther H.L., H. Fleisch, N. Sorgente: Endothelial cells in culture synthesize a potent bone cell active mitogen. Endocrinology 119: 193–201 (1986).

    Article  PubMed  CAS  Google Scholar 

  • Hansen, E.S., K. Soballe, T.B. Henriksen, V.E. Hjortdal, C. Biinger: 99mTc-diophosphonate uptake and hemodynamics in arthritis of the immature dog knee. J. Orthop. Res. 9: 191–202 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Hill, E.L., R. Elde: Distribution of CGRP-0, VIP-, D beta H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat. Cell Tissue Res. 264: 469–480 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Hohmann, E.X., L. Levine, A.H. Tashjian Jr: Vasoactive intestinal peptide stimulates bone resorption via a cyclic adenosine 3′5′ monophosphate dependent mechanism. Endocrinology 112: 1233–1239 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Hulth, A., O. Johnell, L. Lindberg: Demonstration of blood-vessellike structures in cartilaginous callus by antilaminin and antiheparin sulphate proteoglycan antibodies. Clin. Orthop. 254: 289–293 (1990).

    PubMed  Google Scholar 

  • Hunter, W.L., A.L. Arsenault: Endothelial cell division in metaphyseal capillaries during endochondral bone formation in rats. Anat. Rec. 227: 351–358 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Hunter, W.L., A.L. Arsenault, A.B. Hodsman: Rearrangement of the metaphyseal vasculature of the rat growth plate in rickets and rachitic reversal: a model of vascular arrest and angiogenesis renewed. Anat. Rec. 229: 453–461 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Iversen, P.O., G. Nicholaysen, H.B. Benestad: Blood flow to bone marrow during development of anemia or polycythemia in the rat. Blood 79: 594–601 (1992).

    PubMed  CAS  Google Scholar 

  • Jones, A.R., C.C. Clark, C.T. Brighton: The effects of rat microvascular cell products on cultured rat calvarial bone cells. Trans. Orthop. Res. Soc. 17: 188 (1992).

    Google Scholar 

  • Jurvelin, J., T. Lahtinen, I. Kiviranta, I. Arnala, R. Lappalainen, M. Tammi, H.J. Helminen: Blood flow, histomorphology, and elemental composition of the canine femur after physical training or immobilization. Acta Physiol. Scand. 132: 385–389 (1988).

    Article  PubMed  CAS  Google Scholar 

  • Kelly, P.J., J.T. Bronk: Venous pressure and bone formation. Microvasc. Res. 39: 364–375 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Klagsbrun, M., S. Smith: Purification of a cartilage-derived growth factor. J. Biol. Chem. 255: 10859–10866 (1980).

    PubMed  CAS  Google Scholar 

  • Lahtinen, R., T. Lahtinen, T. Romppanen: Bone and bone-marrow blood flow in chronic granulocytic leukemia and primary myelofibrosis. J. Nucl. Med. 23: 218–224 (1982).

    PubMed  CAS  Google Scholar 

  • Laroche, M., C. Ribot, J.L. Puech, J.M. Pouilles, J. Arlet, H. Boccalon, P. Puel, B. Mazieres: Arteriopathy of the lower limbs and osteoporosis in men. Ass. Res. Circ. Osseous News Letter 4: 30–36 (1992).

    Google Scholar 

  • Lindblad, B.E., L.B. Nielsen, A. Bjurholm, E.S. Hansen: Vasoconstrictive action of neuropeptide Y in bone. Trans. Orthop. Res. Soc. 18 (1993).

    Google Scholar 

  • Lucas, P.D.: Reversible reduction in bone blood flow in streptozotocin-diabetic rats. Experientia 43: 894–895 (1987).

    Article  PubMed  CAS  Google Scholar 

  • Lundgaard, A., C. AalkjÅ“r, M.J. Mulvany, A. Bjurholm, E.S. Hansen: Effects of calcitonin gene-related peptide and vasoactive intestinal peptide on resistance vessels isolated from cancellous bone. Trans. Orthop. Res. Soc. 18 (1993).

    Google Scholar 

  • Macintyre, I., M. Zaidi, A.S. Alam, H.K. Datta, B.S. Moonga, P.S. Lidbury, M. Hecker, J.R. Vane: Osteoclastic inhibition — an action of nitric oxide not mediated by cyclic GMP. Proc. Natl. Acad. Sci. USA 88: 2936–2940 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Martiat, P., A. Ferrant, M. Cogneau, A. Bol, C. Michel, J. Rodhain, J.L. Michaux, G. Sokal: Assessment of bone marrow blood flow using positron emission tomography: no relationship with bone marrow cellularity. Br. J. Haematol 66: 307–310 (1987).

    Article  PubMed  CAS  Google Scholar 

  • Mathiassen, B., S. Nielsen, J.S. Johansen, D. Hartwell, J. Ditzel, P. Rodbro, C. Christiansen: Long-term bone loss in insulin-dependent diabetic patients with microvascular complications. J. Diabet. Complic. 4: 145–149 (1990).

    Article  CAS  Google Scholar 

  • McCarthy, I.D., Y. Lang: The relationship between bone blood flow, strontium clearance, and bone turnover in the tibial cortex. Trans. Orthop. Res. Soc. 17: 11 (1992).

    Google Scholar 

  • McClugage, S.J., R.S. McCuskey: Relationship of the microvascular system to bone resorption and growth in situ. Microvasc. Res. 6: 132–134 (1973).

    Article  PubMed  Google Scholar 

  • McInnis, J.C., R.A. Robb, P.J. Kelly: The relationship of bone blood flow, bone tracer deposition, and endosteal new bone formation. J. Lab. Clin. Med. 96: 511–522 (1980).

    PubMed  CAS  Google Scholar 

  • McKinstry, P., J.E. Schnitzer, T. Light, J.A. Ogden, P. Hoffer: Relationship of 99mTc-MDP uptake to regional osseous circulation in skeletal immature and mature dogs. Skeletal Radiol. 8: 115–121 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Monroy, R.L., T.A. Davis, T.B. Nielsen, A.J. Staton: Peripheral blood hematopoietic progenitor/stem cells proliferate to form colonies in liquid culture but require contact with vascular endothelial cells and GM-CSF. Int. J. Cell Cloning 10: 105–115 (1992).

    Article  PubMed  CAS  Google Scholar 

  • Moses, M.A., J. Sudhalter, R. Langer: Identification of an inhibitor of neovascularization from cartilage. Science 248: 1408–1410 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Nanmark, U., F. Buch, T. Albrechtsson: Influence of direct currents on bone vascular supply. Scand. J. Plast. Reconstr. Surg. 22: 113–115 (1988).

    Article  Google Scholar 

  • Peius, L.M.: Modulation of myelopoiesis by prostaglandin E2: Demonstration of a novel mechanism of action in vivo. Immunol. Res. 8: 176–184 (1989).

    Article  Google Scholar 

  • Reddi, A.H., K.E. Kuettner: Vascular invasion of cartilage: correlation of morphology with lysozome, glycosaminoglycans, protease, and protease-inhibitor activity during endochondral bone development. Dev. Biol. 82: 217–223 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Reeve, J., M. Arlot, R. Wootton, C. Edouard, M. Tellez, R. Hesp, J.R. Green, P.J. Meunier: Skeletal blood flow, iliac histomorphometry, and strontium kinetics in osteoporosis: A relationship between blood flow and corrected apposition rate. J. Endocrin. Metab. 66: 1124–1131 (1988).

    Article  CAS  Google Scholar 

  • Roorda, J., C.S. Han, M.B. Wood: In vivo confirmation of bone blood flow control by endothelial derived relaxation factor in the canine tibia. Trans. Orthop. Res. Soc. 17: 8 (1992).

    Google Scholar 

  • Schoutens, A., M. Verhas, N. Dourov, P. Bergmann, F. Caulin, A. Verschaeren, M. Mone, A. Heilporn: Bone loss and bone blood flow in paraplegic rats treated with calcitonin, diphosphonate, and indomethacin. Calcif. Tissue Int. 42: 136–143 (1988).

    Article  PubMed  CAS  Google Scholar 

  • Schoutens, A., M. Verhas, N. Dourov, A. Verschaeren, M. Mone, A. Heilporn: Anemia and marrow blood flow in the rat. Br. J. Haematol. 74: 514–518 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Semb, H.: Experimental limb disuse and bone blood flow. Acta Orthop. Scand. 40: 552–562 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Shapiro, I.M., E.E. Golub, B. Chance, C. Piddington, O. Oshima, O.C. Tuncay, J.C. Haselgrove: Linkage between energy status of perivascular cells and mineralization of the chick growth cartilage. Dev. Biol. 129: 372–379 (1988).

    Article  PubMed  CAS  Google Scholar 

  • Stanka, P., U. Bellack, A. Lindner: On the morphology of the terminal microvasculature during endochondral ossification in rats. Bone Miner. 13: 93–101 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Streeten, E.A., M.L. Brandi: Biology of bone endothelial cells. Bone Miner. 10: 85–94 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Thiele, J., V. Rompcik, S. Wagner, R. Fisher: Vascular architecture and collagen type IV in primary myelofibrosis and polycythemia vera: an immunomorphometric study on trephine biopsies of the bone marrow. Br. J. Hematol 80: 227–234 (1992).

    CAS  Google Scholar 

  • Thompson, T.J., P.D. Owens, D.J. Wilson: Intramembranous osteogenesis and angiogenesis in the chick embryo. J. Anat. 166: 55–65 (1989).

    PubMed  CAS  Google Scholar 

  • Trueta, J.: The role of vessels in osteogenesis. J. Bone Joint Surg 45B: 402–418 (1963).

    Google Scholar 

  • Wickramasinghe, S.N.: Observations on the ultrastructure of sinusoids and reticular cells in human bone marrow. Clin. Lab. Haemat. 13: 263–278 (1991).

    Article  CAS  Google Scholar 

  • Winet, H., J.Y. Bao, R. Moffat: A control model for tibial cortex neovascularization in the bone chamber. J. Bone Miner. Res. 5: 19–30 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Zaidi, M., K. Fuller, P.J.R. Bevis, R.E. Gainesdas, T.J. Chambers, I. Maclntyre: Calcitonin Gene-Related Peptide inhibits osteoclastic bone resorption: A comparative study. Calcif. Tiss. Int. 40: 149–154 (1987).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Plenum Press, New York

About this chapter

Cite this chapter

Hansen, E.S. (1993). Microvascularization, Osteogenesis, and Myelopoiesis in Normal and Pathological Conditions. In: Schoutens, A., Arlet, J., Gardeniers, J.W.M., Hughes, S.P.F. (eds) Bone Circulation and Vascularization in Normal and Pathological Conditions. NATO ASI Series, vol 247. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2838-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2838-8_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-44523-1

  • Online ISBN: 978-1-4615-2838-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics