Skip to main content
SpringerLink
Log in

Integrin Expression and Epithelial Cell Differentiation

  • Chapter
Cell Adhesion Molecules

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 4))

Abstract

The purpose of this paper is to discuss the contribution of a type of cell adhesion receptors, the integrins, to the biology of epithelial cells. While our knowledge on this subject is far from satisfactory, the available evidence suggests that integrins play a critical role in determining many attributes of epithelial cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Argraves, W.S., Suzuki, S., Arai, H., Thompson, K., Pierschbacher, M.D., and Ruoslahti, E., 1987, Amino acid sequence of the human fibronectin receptor. J. Cell Biol. 105:1183–1190.

    Article  PubMed  CAS  Google Scholar 

  • Burridge, K., Molony, L., and Kelly, T., 1987, Adhesion plaques: sites of transmembrane interaction between the extracellular matrix and the actin cytoskeleton. J. Cell Sci. Suppl. 8:211–229.

    PubMed  CAS  Google Scholar 

  • Burridge, K., Fath, K., Kelly, T., Nuckolls, G., and Turner, C., 1988, Focal adhesions: Transmembrane junctions between the extracellular matrix and the cytoskeleton. Ann. Rev. Cell Biol. 4:487–525.

    Article  PubMed  CAS  Google Scholar 

  • Busk, M., Pytela, R., and Sheppard, D., 1992, Characterization of the integrin αVβ6 as a fibronectin-binding protein. J. Biol. Chem. 267:5790–5796.

    PubMed  CAS  Google Scholar 

  • Carter, W.G., Kaur, P., Gil, S.G., Gahr, P.J., and Wayner, E.A., 1990a, Distinct functions for integrins alpha-6-beta-4-bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: Relation to hemidesmosomes. J. Cell Biol. 111:3141–3154.

    Article  PubMed  CAS  Google Scholar 

  • Carter, W.G., Wayner, E.A., Bouchard, T.S., and Kaur, P., 1990b, The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells. J. Cell Biol. 110:1387–1404.

    Article  PubMed  CAS  Google Scholar 

  • Cheresh, D.A., Smith, J.W., Cooper, H.M., and Quaranta, V., 1989, A novel vitronectin receptor integrin (αvβx) is responsible for distinctive adhesive properties of carcinoma cells. Cell 57:59–69.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, H.M., Tamura, R.N., and Quaranta, V., 1991, The major laminin receptor of mouse embryonic stem cells is a novel isoform of the α6β1 integrin. J. Cell Biol. 115:843–850.

    Article  PubMed  CAS  Google Scholar 

  • Dedhar, S. and Saulnier, R., 1990, Alterations in integrin receptor expression in chemically transformed human cells: Specific enhancement of laminin and collagen receptor complexes. J. Cell Biol. 110:481–489.

    Article  PubMed  CAS  Google Scholar 

  • DeLuca, M., Tamura, R.N., Kajiji, S., Bondanza, S., Rossino, P., Cancedda, R., Marchisio, P.C., and Quaranta, V., 1990, Polarized integrin mediates keratinocyte adhesion to basal lamina. Proc. Natl Acad Sci. USA 87:6888–6892.

    Article  CAS  Google Scholar 

  • Geiger, B., 1981, Involvement of vinculin in contact-induced cytoskeletal interactions. Cold Spring Harbor Quant. Biol. XLVI:671–682 (abstract).

    Google Scholar 

  • Giancotti, F.G., and Ruoslahti, E., 1990, Elevated levels on the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell 60:849–859.

    Article  PubMed  CAS  Google Scholar 

  • Gipson, I.K., Spurr-Michaud, S., Tisdale, A., and Keough, M., 1989, Reassembly of the anchoring structures of the corneal epithelium during wound repair in the rabbit. Invest. Ophthal. Vis. Sci. 30:425–434.(abstract)

    PubMed  CAS  Google Scholar 

  • Gumbiner, B., 1992, Epithelial morphogenesis. Cell 69:385–387.

    Article  PubMed  CAS  Google Scholar 

  • Heino, J., Ignotz, R.A., Hemler, M.E., Crouse, C., and Massague, J., 1989, Regulation of cell adhesion receptors by transforming growth factor-β. Concomitant regulation of integrins that share a common β1 subunit. J. Biol. Chem. 264:380–388.

    PubMed  CAS  Google Scholar 

  • Hibbs, M.L., Xu, H., Stacker, S.A., and Springer, T.A., 1991, Regulation of adhesion of ICAM-1 by the cytoplasmin domain of LFA-1 integrin β subunit. Science 251:1611–1613.

    Article  PubMed  CAS  Google Scholar 

  • Hogervorst, F., Kuikman, I., vondemBorne, A.E.G.Kr., and Sonnenberg, A., 1990, Cloning and sequence analysis of β4 cDNA: An integrin subunit that contains a unique 118kDa cytoplasmic domain. EMBO J. 9:765–770.

    PubMed  CAS  Google Scholar 

  • Hynes, R.O., 1992, Integrins: Versatility, modulation and signaling in cell adhesion. Cell 69:11–25.

    Article  PubMed  CAS  Google Scholar 

  • Ignotz, R.A., Heino, J., and Massague, J., 1989, Regulation of cell adhesion receptors by transforming growth factor-β. Regulation of vitronectin receptor and LFA-1. J. Biol. Chem. 264:389–392.

    PubMed  CAS  Google Scholar 

  • Jones, J.C.R., and Green, K.J., 1991, Intermediate filament-plasma membrane interactions. Curr. Opin. Cell Biol. 3:127–132.

    Article  PubMed  CAS  Google Scholar 

  • Jones, J.C.R., Kurpakus, M.A., Cooper, H.M., and Quaranta, V., 1991, A function for the integrin α6β4 in the hemidesmosome. Cell Regul. 2:427–438.

    PubMed  CAS  Google Scholar 

  • Koukoulis, G.K., Virtanen, I., Korhonen, M., Laitinen, L., Quaranta, V., and Gould, V.E., 1991, Immunohistochemical localization of integrins in the normal, hyperplastic and neoplastic breast: Correlation with their functions as receptors and cell adhesion molecules. Am. J. Pathol. 139:787–799.

    PubMed  CAS  Google Scholar 

  • Kurpakus, M.A., Quaranta, V., and Jones, J.C.R., 1991, Surface relocation of α6β4 integrins and assembly of hemidesmosomes in an in vitro model of wound healing. J. Cell Biol. 115:1737–1750.

    Article  PubMed  CAS  Google Scholar 

  • Languino, L.R., Gehlsen, K.R., Wayner, E., Carter, W.G, Engvall, E., and Ruoslahti, E., 1989, Endothelial cells use α2β1 integrin as a laminin receptor. J. Cell Biol. 109:2455–2462.

    Article  PubMed  CAS  Google Scholar 

  • Larjava, H., Peltonen, J., Akiyama, S.K., Yamada, S.S., Gralnick, H.R., Uitto, J., and Yamada, K.M., 1990, Novel function for beta 1 integrins in keratinocyte cell-cell interactions. J. Cell Biol. 110:803–815.

    Article  PubMed  CAS  Google Scholar 

  • Mullis, K.B. and Faloona, F.A., 1987, Specific synthesis of DNA in vitro via a polymerase-catalyzed reaction. Methods. Enzymol. 155:335–350.

    Article  PubMed  CAS  Google Scholar 

  • OToole, T.E., Mandelman, D., Forsyth, J., Shattil, S.J., Plow, E.F., and Ginsberg, M.H., 1991, Modulation of the affinity of (integrin αIIbβ3 (GPIIb-IIIa) by the cytoplasmic domain of αIIb. Science (in press).

    Google Scholar 

  • Pytela, R., Pierschbacher, M.D., and Ruoslahti, E., 1985a, Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor. Cell 40:191–198.

    Article  PubMed  CAS  Google Scholar 

  • Pytela, R., Pierschbacher, M.D., and Ruoslahti, E., 1985b, A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibonectin. Proc. Natl Acad Sci. USA 82:5766–5770.

    Article  PubMed  CAS  Google Scholar 

  • Quaranta, V. and Jones, J.C.R., 1991, The internal affairs of an integrin. Trends Cell Biol. 1:2–4.

    Article  PubMed  CAS  Google Scholar 

  • Quaranta, V., 1991, Epithelial integrins. Cell Differ. Develop. 32:361–366.

    Article  Google Scholar 

  • Rathjen, P.D., Toth, S., Willis, A., Heath, J.K., and Smith, A.G., 1990, Differentiation inhibiting activity is produced in matrix-associated and diffusible forms that are generated by alternate promoter usage. Cell 62:1105–1114.

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez-Boulan, E. and Nelson, W.J., 1989, Morphogenesis of the polarized epithelial cell phenotype. Science 245:718–725.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, M.A., Lechene, C.P., and Ingber, D.E., 1990, Activation of a cytoplasmic signal by integrin α5β1. J. Cell Biol. 111:263a.

    Google Scholar 

  • Sheppard, D., Rozzo, C., Starr, L., Quaranta, V., Erle, D.J., and Pytela, R., 1990, Complete amino acid sequence of a novel integrin β subunit (β6) identified in epithelial cells using the polymerase chain reaction. J. Biol. Chem. 265:11502–11507.

    PubMed  CAS  Google Scholar 

  • Shimizu, Y., Van Seventer, G.A., Horgan, K.J., and Shaw, S., 1990, Regulated expression and binding of three VLA (beta 1) integrin receptors on T cells. Nature 345:250–253.

    Article  PubMed  CAS  Google Scholar 

  • Simons, K. and Fuller, S.D., 1985, Cell surface polarity in epithelia. Ann. Rev. Cell. Biol. 1:243–288.

    Article  PubMed  CAS  Google Scholar 

  • Sonnenberg, A., Modderman, P.W., and Hogervorst, F., 1988, Laminin receptor on platelets is the integrin VLA-6. Nature 336:487–489.

    Article  PubMed  CAS  Google Scholar 

  • Springer, T.A., 1990, Adhesion receptors of the immune system. Nature 346:425–434.

    Article  PubMed  CAS  Google Scholar 

  • Staehelin, L.A., 1974, Structure and function of intercellular junctions. Int. Rev. Cytol. 39:191–278.

    Article  PubMed  CAS  Google Scholar 

  • Stepp, M.A., Spurrmichaud, S., Tisdale, A., Elwell, J., and Gipson, I.K., 1990, Alpha-6-beta-4 integrin heterodimer is a component of hemidesmosomes. Proc. Natl. Acad. Sci. USA 87:8970–8974.

    Article  PubMed  CAS  Google Scholar 

  • Suzuki, S., Argraves, W.S., Arai, H., Languino, L.R., Pierschbacher, M.D., and Ruoslahti, E., 1987, Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs. J. Biol. Chem.

    Google Scholar 

  • Suzuki, S. and Naitoh, Y., 1990, Amino acid sequence of a novel integrin β4 subunit and primary expressio of the mRNA in epithelial cells. EMBO J. 9:757–763.

    PubMed  CAS  Google Scholar 

  • Takada, Y., Huang, C., and Hemler, M.E., 1987, Fibronectin receptor structures in the VLA family of heterodimers. Nature 326:607–609.

    Article  PubMed  CAS  Google Scholar 

  • Tamura, R.N., Rozzo, C., Starr, L., Chambers, J., Reichardt, L.F., Cooper, H.M., and Quaranta, V., 1990, Epithelial integrin α6β4: Complete primary structure of α6 and variant forms of β4. J. Cell Biol. 111:1593–1604.

    Article  PubMed  CAS  Google Scholar 

  • Tamura, R.N., Cooper, H.M., Collo, G., and Quaranta, V., 1991, Cell-type specific integrin variants with alternative a chain cytoplasmic domains. Proc. Natl. Acad Sci. USA 88:10183–10187.

    Article  PubMed  CAS  Google Scholar 

  • Wayner, E.A. and Carter, W.G., 1987, Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique α and common β subunits. J. Cell. Biol. 105:1873–1884.

    Article  PubMed  CAS  Google Scholar 

  • Wayner, E.A., Carter, W.G., Piotrowicz, R.S., and Kunicki, T.J., 1989, The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix receptors: Preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa. J. Cell Biol. 107:1881–1891.

    Article  Google Scholar 

  • Werb, Z., Tremble, P.M., Behrendtsen, O., Crowley, E., and Damsky, C.H., 1989, Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J. Cell Biol. 109:877–889.

    Article  PubMed  CAS  Google Scholar 

  • Wolf, G.T., Carey, T.E., Schmaltz, S.P., McClatchey, K.D., Poore, J., Glaser, L., Hayashida, D.J.S., and Hsu, S., 1990, Altered antigen expression predicts outcome in squamous cell carcinoma of the head and neck. J. Natl Cancer Inst. 82:1566–1572.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell Biology, NX-7 The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA

    Vito Quaranta

Authors
  1. Vito Quaranta
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Dana-Farber Cancer Institute, Boston, Massachusetts, USA

    Martin E. Hemler

  2. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Plenum Press, New York

About this chapter

Cite this chapter

Quaranta, V. (1993). Integrin Expression and Epithelial Cell Differentiation. In: Hemler, M.E., Mihich, E. (eds) Cell Adhesion Molecules. Pezcoller Foundation Symposia, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2830-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2830-2_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-44496-8

  • Online ISBN: 978-1-4615-2830-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation