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In vitro models of multiple drug resistance

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Anticancer Drug Resistance

Part of the book series: Cancer Treatment and Research ((CTAR,volume 73))

Abstract

The emergence of drug resistance in many ways reflects evolution; those cells capable of surviving exposure to an environmental stress propagate. This is particularly important in cancer, where it has been estimated that 90% of the 500,000 annual cancer fatalities in the United States are influenced by drug resistance [1]. Therefore, understanding the biochemical underpinnings of resistance is likely to be essential for developing new therapies to avoid or circumvent clinical resistance. The outcome of this therapeutic strategy will lead to the development of new agents or drug regimens that either reduce the frequency of drug resistance or eliminate drug resistance when it occurs and thereby improve cancer treatment.

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  1. Lee M. Greenberger
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  2. Dalia Cohen
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Greenberger, L.M., Cohen, D., Horwitz, S.B. (1994). In vitro models of multiple drug resistance. In: Goldstein, L.J., Ozols, R.F. (eds) Anticancer Drug Resistance. Cancer Treatment and Research, vol 73. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2632-2_5

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