Skip to main content
SpringerLink
Log in

Screening for Anticancer Leads from Marine Organisms in a Mechanism-Based Drug Discovery Program

  • Chapter
Anticancer Drug Discovery and Development: Natural Products and New Molecular Models

Part of the book series: Developments in Oncology ((DION,volume 74))

Abstract

Current estimates of the American Cancer Society are that during 1992 some 1.1 million Americans will have been diagnosed as having cancer. Additionally, over 500,000 people succumb annually to this disease. At the top of the list of fatal cancers (deaths/yr) is lung cancer (146,000) (1). The other major types of cancers (deaths/yr) are colon/rectum (51,000), breast (46,300), prostate (34,000), non-Hodgkin’s lymphomas (19,400) and leukemias (18,000). Chemotherapy represents an important tool to combat these and other cancers since more than 2 0 percent of cancer patients undergo this treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cancer Statistics Review 1973–1989, National Cancer Institute, NIH Pub. No. 92-2789, BA Miller, LA Gloeckler Ries, BF Hankey, CL Kosary, BK Edwards (eds), p I.21, 1992.

    Google Scholar 

  2. Cancer Principles & Practice of Oncology, VT DeVita Jr, S Hellman, SA Rosenberg (eds), JB Lippincott Co., Philadelphia, p 277, 1985.

    Google Scholar 

  3. Pettit GR: In: Biosynthetic Products for Cancer Chemotherapy, Vol. 1, Plenum Press, New York, 1977.

    Google Scholar 

  4. Farber S, Toch R, Sears EM, Pinkel D: In: Advances in Cancer Research, JP Greenstein, A Haddow (eds), 4:1, 1956.

    Google Scholar 

  5. Schmitz FJ, Bowden BF, Toth SI: Antitumor and cytotoxic compounds from marine organisms. In: Marine Biotechnology, Vol. 1: Pharmaceutical and Bioactive Natural Products, DH Attaway, OR Zaborsky (eds), Plenum Press, New York, 1993.

    Google Scholar 

  6. Munro MHG, Luibrand RT, Blunt JW: Bioorganic Marine Chemistry, Vol. 1. The Search for Antiviral and Anticancer Compounds from Marine Organisms, PJ Scheuer (ed), 1987.

    Google Scholar 

  7. Suffness M, Douros JD: J. Nat. Prod. 45:1, 1982.

    PubMed  CAS  Google Scholar 

  8. Biosynthetic Products for Cancer Chemotherapy, Vol. 5, GR Pettit, GM Cragg, CL Herald (eds), Elsevier, 1985.

    Google Scholar 

  9. Weber G: Cancer Res. 43:3466, 1983.

    PubMed  CAS  Google Scholar 

  10. Bishop MJ: Science 235:305, 1987.

    PubMed  CAS  Google Scholar 

  11. Barbacid M: Carcinogen. 7:1037, 1986.

    CAS  Google Scholar 

  12. Heldin C-H, Betsholtz C, Claesson-Welsh L, Westermark B: Biochim. Biophys. Acta 907:219, 1987.

    PubMed  CAS  Google Scholar 

  13. Nishimura S, Sekiya T: Biochem. J. 243:312, 1987.

    Google Scholar 

  14. Weinberg RA: Science 230:770, 1985.

    PubMed  CAS  Google Scholar 

  15. Slate DL: In: Mechanisms of Carcinogenesis, EK Weisburger (ed) , Kluwer Acad. Publishers, p 106, 1989.

    Google Scholar 

  16. Cooper GM: Elements of Human Cancer, Jones and Bartlett Publishers, 22, 1992.

    Google Scholar 

  17. Varmus HE: Ann. Rev. Genet. 18:553, 1984.

    PubMed  CAS  Google Scholar 

  18. Weber G: Biochem. Soc. Trans. 18:74, 1990.

    PubMed  CAS  Google Scholar 

  19. Yarden Y, Ullrich A: Annual Rev. Biochem. 57:4–43, 1988.

    Google Scholar 

  20. Hunter T: Cell 50:823, 1987.

    PubMed  CAS  Google Scholar 

  21. Powis G: Trends Pharmacol. Sci. 12:188, 1991.

    PubMed  CAS  Google Scholar 

  22. Kenyon GL, Garcia GA: Med. Research Rev. 7:389, 1987.

    CAS  Google Scholar 

  23. Klein G, Klein E: Nature 315:190, 1985.

    PubMed  CAS  Google Scholar 

  24. Chang CJ, Grahlen RL: J. Nat. Prod. 55:1529, 1992.

    PubMed  CAS  Google Scholar 

  25. Wong TW, Goldberg AR: J. Biol. Chem. 258:1022–1025, 1983.

    PubMed  CAS  Google Scholar 

  26. Wong TW, Goldberg AR: J. Biol. Chem. 259:3127, 1987.

    Google Scholar 

  27. Farley K, Mett H, McGlynn E, et al: Anal. Biochem. 203:151, 1992.

    PubMed  CAS  Google Scholar 

  28. Onoda T, Iinuma H, Sasaki Y, et al: J. Nat. Prod. 52:1252, 1989.

    PubMed  CAS  Google Scholar 

  29. Graziani Y, Erikson E, Erikson RL: Eur. J. Biochem. 135:583, 1983.

    PubMed  CAS  Google Scholar 

  30. Hagiwara M, Inoue S, Tanaka T, et al: Biochem. Pharmacol. 37:2987, 1988.

    PubMed  CAS  Google Scholar 

  31. Geahlen RL, Koonchanok NM, McLaughlin JJ, Pratt DE: J. Nat. Prod. 52:982, 1989.

    PubMed  CAS  Google Scholar 

  32. Ogawara H, Akiyama T, Ishida J, et al: J. Antibiot. 39:606, 1986.

    PubMed  CAS  Google Scholar 

  33. Umezawa H, Imoto M, Sawa T, et al: J. Antibiot. 39:170, 1986.

    PubMed  CAS  Google Scholar 

  34. Shiraishi T, Owada MK, Tatsuka M, et al: Cancer Res. 49:2374, 1989.

    PubMed  CAS  Google Scholar 

  35. Uehara Y, Fukazawa H, Murakami Y, Mizuno S: Biochem. Biophys. Res. Commun. 163:803, 1989.

    PubMed  CAS  Google Scholar 

  36. Donella-Deana A, Monti E, Pinna LA: Biochem. Biophys. Res. Commun. 160:1309, 1989.

    PubMed  CAS  Google Scholar 

  37. Kreuter M-H, Leake RE, Rinaldi F, et al: Comp. Biochem. Physiol. 97B:151, 1990.

    CAS  Google Scholar 

  38. Lee RH, Slate DL, Moretti R, et al: Biochem. Biophys. Res. Commun. 184:765–772, 1992.

    PubMed  CAS  Google Scholar 

  39. Schmitz FJ, Bloor SJ: J. Org. Chem. 53:3922, 1988.

    CAS  Google Scholar 

  40. Tamaoki T, Nakano H: Biotechnology 8:732, 1990.

    PubMed  CAS  Google Scholar 

  41. Blumberg PM: Cancer Res. 48:1, 1988.

    PubMed  CAS  Google Scholar 

  42. Wender PA, Koehler KF, Sharkey NA, et al: Proc. Nat. Acad. Sci. USA 83:4214, 1986.

    PubMed  CAS  Google Scholar 

  43. Wender PA, Cribbs CM, Koehler KF, et al: Proc. Nat. Acad. Sci. USA 85:7197, 1988.

    PubMed  CAS  Google Scholar 

  44. Sugimura T, Fujiki H: In: Gann Monograph on Cancer Research, Vol. 29, A Makita, S Tsuiki, H Fujiki, L Warren (eds), Univ. Tokyo Press, Tokyo, p 3, 1983.

    Google Scholar 

  45. Fujiki H, Sugimura T: Adv. Cancer Res. 49:223, 1987.

    PubMed  CAS  Google Scholar 

  46. Nishizuka Y: Nature 308:693, 1984.

    PubMed  CAS  Google Scholar 

  47. Takahashi I, Saitoh Y, Yoshida M, et al: J. Antibiot. 52:571, 1989.

    Google Scholar 

  48. Furusaki A, Hashibia N, Matsumoto T, et al: J. Chem. Soc. Chem. Cominun. 800, 1978.

    Google Scholar 

  49. Poste G: Cancer Treat. Rep. 70:183–199, 1986.

    PubMed  CAS  Google Scholar 

  50. Nicolson GL: Biochim. Biophys. Acta 948:175, 1988.

    PubMed  CAS  Google Scholar 

  51. Yagel S, Khokha R, Denhardt DT, et al: J. Natl. Cancer Inst. 81:768, 1989.

    PubMed  CAS  Google Scholar 

  52. Teranova VP, Maslow D, Markus G: Cancer Res. 49: 4835, 1989.

    Google Scholar 

  53. Liotta LA, Stetler-Stevenson W: J. Natl. Cancer Inst. 81:556, 1989.

    PubMed  CAS  Google Scholar 

  54. Hart IR, Goode NT, Wilson RE: Biochim. Biophys. Acta 989:65, 1989.

    PubMed  CAS  Google Scholar 

  55. Quantain B, Murphy G, Breathnach R: Biochem. 28: 5327, 1989.

    Google Scholar 

  56. Wilson BJ: Miscellaneous Penicillium toxins. In: Microbial Toxins, Vol. VI, A Ciegler, et al (eds), Academic Press, New York, p 460, 1971.

    Google Scholar 

  57. Nagai M, Natsumeda Y, Konno Y, et al: Cancer Res. 51:3886, 1991.

    PubMed  CAS  Google Scholar 

  58. Warr JR, Atkinson GF: Physiol. Rev. 68:1, 1988.

    PubMed  CAS  Google Scholar 

  59. Endicott JA, Ling V: Ann. Rev. Biochem. 58:137, 1989.

    PubMed  CAS  Google Scholar 

  60. Guild BC, Mulligan RC, Gros P, Houseman DE: Proc. Natl. Acad. Sci. USA 85:1595, 1988.

    PubMed  CAS  Google Scholar 

  61. Inaba M, Maruyama E: Cancer Res. 48:2064, 1988.

    PubMed  CAS  Google Scholar 

  62. Nogae I, Kohno K, Kituchi J, et al: Biochem. Pharmacol. 38:519, 1989.

    PubMed  CAS  Google Scholar 

  63. Sesin DF, Gaskell SJ, Ireland CM: Bull. Chim. Soc. Belg. 95:853, 1988.

    Google Scholar 

  64. Schmitz FJ, Ksebati MB, Chang JS, et al: J. Org. Chem. 54:3463, 1989.

    CAS  Google Scholar 

  65. McDonald LA, Ireland CM: J. Nat. Prod. 55:376, 1992.

    PubMed  CAS  Google Scholar 

  66. Krebs HC: Fortschr. Chem. Org. Naturst. 49:151, 1986.

    PubMed  CAS  Google Scholar 

  67. Bergquist PR, Wells RJ: In: Marine Natural Products, Chemical and Biological Perspectives, PJ Scheuer (ed), Academic Press, New York, Vol. V, Chapter 1, 1983.

    Google Scholar 

  68. Crews P, Naylor S: Fortschr. Chem. Org. Naturst. 48:203, 1985.

    PubMed  CAS  Google Scholar 

  69. Faulkner DJ: Nat. Prod. Rept. 5:613, 1988.

    CAS  Google Scholar 

  70. Crews P, Kakou Y, Quinoa E: J. Am. Chem. Soc. 110: 4365, 1988.

    CAS  Google Scholar 

  71. Omar S, Tenenbaum L, Manes LV, Crews P: Tetrahedron Lett. 29:5489, 1988.

    CAS  Google Scholar 

  72. Crews P, Manes LV, Boehler M: Tetrahedron Lett. 27:2797, 1986.

    CAS  Google Scholar 

  73. Inman WD, Crews P: J. Amer. Chem. Soc. 111:2822, 1989.

    CAS  Google Scholar 

  74. Zabriskie TM, Klocke JA, Ireland CM, et al: J. Am. Chem. Soc. 108:3123, 1986.

    CAS  Google Scholar 

  75. Braekman JC, Daloze D, Moussiaux B, Riccio R: J. Nat. Prod. 50:994, 1987.

    CAS  Google Scholar 

  76. Chan WR, Tinto WF, Manchand PS, Todaro LJ: J. Org. Chem. 52:3091, 1987.

    CAS  Google Scholar 

  77. deSilva ED, Andersen RJ, Allen TM: Tetrahedron Lett. 31:489, 1990.

    Google Scholar 

  78. Wilkinson CR: In: Endosymbiosis and Cell Biology, W Schwemmler, HEA Schenk (eds), Walter de Gruyter & Co., New York, Vol. I, p 553, 1980.

    Google Scholar 

  79. Mitsunobu D, Ishida T, Kobayashi M, Kitagawa I: J. Org. Chem. 56:3629, 1991.

    Google Scholar 

  80. Kobayashi M, Tanaka J, Katori T, Kitagawa I: Chem. Pharm. Bull. 38:2960, 1990.

    PubMed  CAS  Google Scholar 

  81. Kobayashi M, Tanaka J, Katori T, et al: Tetrahedron Lett. 30:2963, 1989.

    CAS  Google Scholar 

  82. Kobayashi M, Tanaka J, Katori T, et al: Chem. Pharm. Bull. 38:2409, 1990.

    CAS  Google Scholar 

  83. Kitagawa I, Kobayashi M, Katori T, et al: J. Am. Chem. Soc. 112:3710, 1990.

    CAS  Google Scholar 

  84. Carmely S, Kashman Y: Tetrahedron Lett. 26:511, 1985.

    CAS  Google Scholar 

  85. Kato Y, Fusetani N, Matsunaga S, et al: Tetrahedron Lett. 49:6225, 1987.

    Google Scholar 

  86. Tanaka J, Higa T, Kobayashi M, Kitagawa I: Chem. Pharm. Bull. 38:2967, 1990.

    CAS  Google Scholar 

  87. Kobayashi J, Murayama T, Ohizumi Y, et al: Tetrahedron Lett. 30:4833, 1989.

    CAS  Google Scholar 

  88. Nakamura H, Kobayashi J, Ohizumi Y, Hirata Y: Tetrahedron Lett. 25:5401, 1984.

    CAS  Google Scholar 

  89. Kitagawa I, Lee NK, Kobayashi M, Shibuya H: Tetrahedron 47:2169, 1991.

    CAS  Google Scholar 

  90. Todd JS, Alvi KA, Crews P: Tetrahedron Lett. 33: 441–442, 1992.

    CAS  Google Scholar 

  91. Ishibashi M, Moore RE, Patterson GML, et al: J. Org. Chem. 51:5300, 1986.

    CAS  Google Scholar 

  92. Keifer PA, Schwartz RE, Koker MES, et al: J. Org. Chem. 56:2965–2975, 1991.

    CAS  Google Scholar 

  93. Gunasekera SP, Granick S, Longley RE: J. Nat. Prod. 52:757–761, 1989.

    PubMed  CAS  Google Scholar 

  94. Fathi-Afshar R, Allen TM: Can. J. Chem. 66:45, 1988.

    CAS  Google Scholar 

  95. Nakatsu T, Faulkner DJ: Tetrahedron Lett. 25: 935, 1984.

    CAS  Google Scholar 

  96. Bergquist PR: New Zealand J. Zoology 7:443, 1980.

    Google Scholar 

  97. Bergquist PR, Ayling AM, Wilkinson CR: Marine Ecology 9:291, 1988.

    Google Scholar 

  98. Norton RS, Croft KD, Wells RJ: Tetrahedron 37:2341, 1981.

    CAS  Google Scholar 

  99. Salva J, Faulkner DJ: J. Nat. Prod. 53:757, 1990.

    CAS  Google Scholar 

  100. Horton P, Inman W, Crews P: J. Nat. Prod., 53:143, 1990.

    CAS  Google Scholar 

  101. Dunlop RW, Kazlauskas R, March G, et al: Aust. J. Chem. 35:95, 1982.

    CAS  Google Scholar 

  102. Rodriguez J, Quinoa E, Riguera R, et al: Tetrahedron 48:6667, 1992.

    CAS  Google Scholar 

  103. Kobayashi J, Cheng J, Ishibashi M, et al: J. Chem. Soc. Perkin Trans. 1:1135, 1991.

    Google Scholar 

  104. Alvi KA, Diaz MC, Crews P, et al: J. Org. Chem. 57:6604, 1992.

    CAS  Google Scholar 

  105. Kanazawa S, Fusetani N, Matsunaga S: Tetrahedron 48:5467, 1992.

    CAS  Google Scholar 

  106. Okami Y: Microb. Ecol. 12:65, 1986.

    CAS  Google Scholar 

  107. Gustafson K, Roman M, Fenical W: J. Am. Chem. Soc. 111:7519, 1989.

    CAS  Google Scholar 

  108. Tapiolas DM, Roman M, Fenical W, et al: J. Am. Chem. Soc. 113:4682, 1991.

    Google Scholar 

  109. Poch GK, Gloer JB: J. Nat. Prod. 52:257, 1989.

    PubMed  CAS  Google Scholar 

  110. Pisano MA, Sommer MJ, Brancaccio L: Appld. Microbiol. Biotechnol. 31:609, 1989.

    CAS  Google Scholar 

  111. Biology of Anaerobic Microorganisms, JB Zehnder (ed), J. Wiley & Sons, New York, 1988.

    Google Scholar 

  112. Jones WJ, Nagle DP Jr, Whitman WB: Microbiol. Rev. 51:135, 1987.

    PubMed  CAS  Google Scholar 

  113. Gupta R: Archaebacteria. In: The Bacteria, Vol. 8, CR Woese, RS Wolfe (eds), Academic Press, New York, 1985.

    Google Scholar 

  114. Gupta R, Woese CR: Curr. Microbiol, 4:245, 1980.

    CAS  Google Scholar 

  115. Balch WE, Wolfe RS: Appl. Environ. Microbiol. 32: 781, 1976.

    PubMed  CAS  Google Scholar 

  116. Wofford NQ, Beay PS, Mclnerney MJ: J. Bacteriol. 167:179, 1986.

    PubMed  CAS  Google Scholar 

  117. Moore RE, Patterson ML, Carmichael WW: New Pharmaceuticals from cultured blue-green algae. In: Biomedical Importance of Marine Organisms, DG Fautin (ed), 13:143, 1988.

    Google Scholar 

  118. Carmichael WW: Algal toxins. In: Advances in Botanical Research, JA Callow (ed), Academic Press, London, 12:47, 1986.

    Google Scholar 

  119. Aaronson S: Descriptive biochemistry and physiology of the Chrysophycease (with some comparisons to Prymnesiophyceae). Biochem. Phys. Protozoa 3:117, 1980.

    CAS  Google Scholar 

  120. Gerwick WH, Jiang ZD, Agarwal SK, Farmer BT: Tetrahedron 48:2313, 1992.

    CAS  Google Scholar 

  121. Marine Natural Products: Metabolites of Marine Algae and Herbivorous Marine Molluscs, (ref. 48c).

    Google Scholar 

  122. Proteau PJ, Gerwick WH: Tetrahedron Lett. 33:4393, 1992.

    CAS  Google Scholar 

  123. Boyd MR: Principles & Practice of Oncology 3:1, 1989.

    Google Scholar 

Download references

Authors
  1. P. Crews
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. L. Slate
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. H. Gerwick
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. J. Schmitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Schatzman
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B. Strulovici
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. P. Cannon
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. L. M. Hunter
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. School of Medicine, Wayne State University, Detroit, Michigan, USA

    Frederick A. Valeriote , Thomas H. Corbett  & Laurence H. Baker ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Crews, P. et al. (1994). Screening for Anticancer Leads from Marine Organisms in a Mechanism-Based Drug Discovery Program. In: Valeriote, F.A., Corbett, T.H., Baker, L.H. (eds) Anticancer Drug Discovery and Development: Natural Products and New Molecular Models. Developments in Oncology, vol 74. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2610-0_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2610-0_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6118-3

  • Online ISBN: 978-1-4615-2610-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation