Abstract
Screening of both synthetic organic compounds and extracts of natural products has had an impressive history of identifying active cytotoxic agents. Indeed, the majority of compounds, which have a significant role in clinical therapy at present were discovered either as a direct consequence of such screening or a subsequence of synthesis of analogs of lead drugs (Table 1). Specifically, the discovery of cytotoxic agents from natural sources has had a rich and fruitful past with the identification of agents such as vincristine and taxol from plants and a number of antibiotics such as adriamycin from fermentations.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Sikic BI: Anticancer drug discovery. J. Nat. Cancer Inst. 83:738–740, 1991.
Devlin JP, Edwards OE, Gorham PR, et al: Anatoxina, a toxic alkaloid from Anabaena flos-aquae NRC-44h. Canad. J. Chem. 55:1367–1371, 1977.
Mynderse JS, Moore RE, Kashiwagi M, Norton TR:Antileukemia activity in the Oscillatoriaceae: Isolation of debromoaplysiatoxin from Lyngbya. Science 196:538–540, 1977.
Cardellina JH, Marner FJ, Moore RE: Seaweed dermatitis: Structure of lyngbyatoxin A. Science 204: 193–195, 1979.
Moore RE, Patterson GML, Enteroth M, et al: Binding studies of [3H]lyngbyatoxin and [3H]debromoaplysiatoxin to the phorbol ester receptor in a mouse epidermal particulate fraction. Carcinogenesis 7:641–644, 1986.
Ishibashi M, Moore RE, Patterson GML, et al: Scytophycins, cytotoxic and antimycotic agents from the cyanophyte Scytonema pseudohofmanni. J. Org. Chem. 51:5300–5306, 1986.
Moore RE, Patterson GML, Mynderse JS, et al: Toxins from cyanophytes belonging to the Scytonemataceae. Pure Appl. Chem. 58:263–271, 1986.
Tachibana K, Echcucr PJ, Taukitani Y, et al: Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria. J. Amer. Chem. Soc. 103:2469–2471, 1981.
Uemura D, Takahashi K, Yamamoto T, et al: Norhalichondrin A, an antitumor polyether macrolide from a marine sponge. J. Amer. Chem. Soc. 107:4796–4798, 1985.
Chun HG, Davies B, Hoth D, et al: Didemnin B: The first marine compound entering clinical trials as an antineoplastic agent. Investigat. New Drugs 4:279–284, 1986.
Pettit GR, Herald CL, Doubek DL, Herald DL: Isolation and structure of bryostatin I. J. Amer. Chem. SOC. 104:6846–6848, 1982.
Corbett T, Valeriote F, Baker L: Is the P388 murine tumor no longer adequate as a drug discovery model? Investigat. New Drugs 5:3–20, 1987.
Corbett TH, Valeriote FA, Polin L, et al: Discovery of solid tumor active agents using a soft-afar-colony-formation disk-diffusion-assay. FA Valeriote, TH Corbett, LH Baker (eds), Springer Science+Business Media New York, Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development, pp 35–87, 1992.
Corbett TH, Valeriote FA: Rodent models in experimental chemotherapy. In: The Use of Rodent Tumors in Experimental Cancer Therapy: Conclusions and Recommendations. RF Kallman (ed), Pergamon Press, Chapter 50, pp 233–247, 1987.
Owen, SP, Smith, CG: Cytotoxicity and antitumor properties of the abnormal nucleoside tubercidin (NSC-56408). Cancer Chem. Rep., 36:19–22, 1964.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Valeriote, F., Moore, R.E., Patterson, G.M.L., Paul, V.J., Scheuer, P.J., Corbett, T. (1994). Discovery of Natural Products from Microalgae and Marine Organisms. In: Valeriote, F.A., Corbett, T.H., Baker, L.H. (eds) Anticancer Drug Discovery and Development: Natural Products and New Molecular Models. Developments in Oncology, vol 74. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2610-0_1
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2610-0_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6118-3
Online ISBN: 978-1-4615-2610-0
eBook Packages: Springer Book Archive