Skip to main content
SpringerLink
Log in
Book cover

Purine and Pyrimidine Metabolism in Man VIII pp 35–38Cite as

Renal Urate Hypoexcretion in Polynesian Women is not as Severe as in United Kingdom (UK) Women with Familial Juvenile Hyperuricaemic Nephropathy (FJHN)

  • Chapter

  • 17 Accesses

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 370))

Abstract

Polynesians have a predisposition to hyperuricaemia and gout. A number of risk factors have been identified including obesity, hyperglycaemia and hypertriglyceridaemia, however renal disease is not one of the associated risk factors. Studies in healthy Maori men1 established that the factor which put them at risk for hyperuricaemia and gout was an extremely reduced fractional clearance of uric acid, FEur (uric acid clearance factored by Creatinine clearance x 100%)1. Asymptomatic hyperuricaemia was identified in 23% of healthy Maori men, with a mean FEur (3.9%) lower than in the UK gouty male (5.4%). Even normouricaemic Maori males had a low FEur (4.9%) compared with UK males (8.1%).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. T. Gibson, R. Waterworth, P. Hatfield, G. Robinson, and K. Bremner, Hyperuricaemia, gout and kidney function in young New Zealand Maori men, Br. J. Rheumatol. 23:276 (1984).

    Article  PubMed  CAS  Google Scholar 

  2. J.S. Cameron, F. Moro, H.A. Simmonds, Gout, uric acid and purine metabolism in paediatric nephrology, Review, Ped. Nephrol. 7:105 (1993).

    Article  CAS  Google Scholar 

  3. J.G. Puig, A.D. Michan, M.L. Jiminez, C.P. de Ayala, F.A. Mateos, C.F. Capitan, E. de Miguel, J.B. Gijon, Female gout; clinical spectrum and uric acid metabolism, Arch. Int. Med. 151:726 (1991).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Purine Research Laboratory, UMDS Guy’s Hospital, London, UK

    M. B. McBride & H. A. Simmonds

  2. Department of Renal Medicine, Wellington Hospital, Porirua, NZ

    P. J. Hatfield

  3. Department of Clinical Chemistry, Wellington Hospital, Porirua, NZ

    M. Jackson

  4. Department of Dietetic Services, Wellington Hospital, Porirua, NZ

    J. McCaskey

  5. Mitsubishi Health Centre, Porirua, NZ

    R. Graham

Authors
  1. M. B. McBride
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. A. Simmonds
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. J. Hatfield
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Jackson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. McCaskey
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. Graham
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Indiana University School of Medicine, Indianapolis, Indiana, USA

    Amrik Sahota

  2. Indiana University, Bloomington, Indiana, USA

    Milton W. Taylor

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

McBride, M.B., Simmonds, H.A., Hatfield, P.J., Jackson, M., McCaskey, J., Graham, R. (1995). Renal Urate Hypoexcretion in Polynesian Women is not as Severe as in United Kingdom (UK) Women with Familial Juvenile Hyperuricaemic Nephropathy (FJHN). In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2584-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2584-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6105-3

  • Online ISBN: 978-1-4615-2584-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation