Abstract
Renal vasoconstriction is accompanied by markedly reduced urinary uric acid excretion and hyperuricemia. FNAH (McKusik 16200) is an autosomal dominant disease characterized by severe uric acid underexcretion, usually preceding renal insufficiency (1). Because the pathogenetic role of increased serum urate concentration is controversial, we examined renal hemodynamics in patients with FNAH to assess whether renal vasoconstriction mediates the disturbance of uric acid metabolism.
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References
McKusick VA. Mendelian Inheritance in Man: Catalogs of Autosomal Dominant, Autosomal Recessive and X-linked Phenotypes. 9th ed. Baltimore; Johns Hopkins University Press; 1990:648.
Friedenberg MJ, Walz BJ, McAlister WH, Locksmith JP, Gallagher TL. Roentgen size of normal kidneys. Radiology 1965;84:1022–1030.
Puig JG, Miranda MaE, Mateos ME, et al. Hereditary nephropathy associated with hyperuricemia and gout. Arch Intern Med 1993;153:357–365.
Steele TH, Rieselbach RE. The contribution of residual nephrons within the chronically diseased kidney to urate homeostasis in man. Am J Med. 1967;43:876–886.58.
Garyfallos A, Magoula I, Tsapas G. Evaluation of the renal mechanisms for urate homeostasis in uremic patients by probenecid and pyrazinamide test. Nephron 1987;46:273–280.
Puig JG, Mateos FA, Jiménez ML, Ramos TH. Renal excretion of hypoxanthine and xanthine in primary gout. Am J Med 1988;85:533–537.
Messerli FH, Frohlich ED, Dreslinski GR, Suarez DH, Aristimuno GG. Serum uric acid in essential hypertension: An indicator of renal vascular involvement. Ann Intern Med 1980;93:817–821.
Ferris TF, Gorden P. Effect of angiotensin and norepinephrine upon urate clearance in man. Am J Med 1968;44:359–365.
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© 1995 Springer Science+Business Media New York
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Mateos, F.A., Puig, J.G. (1995). Renal Hemodynamic in Familial Nephropathy Associated with Hyperuricemia (FNAH). In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2584-4_8
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DOI: https://doi.org/10.1007/978-1-4615-2584-4_8
Publisher Name: Springer, Boston, MA
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