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Purine and Pyrimidine Metabolism in Man VIII pp 219–225Cite as

Purine and Pyrimidine Metabolisms in Human Gliomas, Melanomas and Colon Carcinomas Xenografts, Relation to their Cytogenetic Profile

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 370))

Abstract

Cytogenetic analyses performed on human solid tumors have shown, for some of them characteristic patterns of chromosomes anomalies. To understand the meaning of recurrent chromosomal imbalances, it was postulated that they could be related to specific metabolic modifications. This hypothesis was first tested on colorectal carcinomas1, 2, 3 and verified on gliomas, by comparing tumor samples to corresponding normal tissue4, 5. In an attempt to precise the role of chromosomal aberrations, it appeared of interest to develop a metabolic study of three tumors, presenting either similar or distinct cytogenetic patterns, in order to compare their metabolic patterns.

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Authors and Affiliations

  1. Commissariat à l’Energie Atomique, DSV/DPTE/LCG, BP 6 99265, Fontenay aux Roses cedex, France

    V. Bardot, J. Beaumatin & C. Luccioni

  2. URA 620 CNRS, Section Biologie, Institut Curie, 26 rue d’Ulm, 75231, Paris cedex 05, France

    A. M. Dutrillaux, D. Lefrançois, F. Apiou & B. Dutrillaux

Authors
  1. V. Bardot
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  2. A. M. Dutrillaux
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  3. J. Beaumatin
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  4. D. Lefrançois
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  5. F. Apiou
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  6. B. Dutrillaux
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  7. C. Luccioni
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Editor information

Editors and Affiliations

  1. Indiana University School of Medicine, Indianapolis, Indiana, USA

    Amrik Sahota

  2. Indiana University, Bloomington, Indiana, USA

    Milton W. Taylor

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© 1995 Springer Science+Business Media New York

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Bardot, V. et al. (1995). Purine and Pyrimidine Metabolisms in Human Gliomas, Melanomas and Colon Carcinomas Xenografts, Relation to their Cytogenetic Profile. In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2584-4_47

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  • DOI: https://doi.org/10.1007/978-1-4615-2584-4_47

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6105-3

  • Online ISBN: 978-1-4615-2584-4

  • eBook Packages: Springer Book Archive

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