Abstract
Amido phosphoribosyltransferase (PRTase) catalyses the first reaction of the pathway for de novo biosynthesis of purine nucleotides:
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References
Allegra, C.J. Fine, R.L., Drake, J.C. and Chabner, B.A., 1986, The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells, J. Biol. Chem., 261: 6478.
Hartman, S.C., 1963, Phosphoribosyl pyrophosphate amidotransferase: purification and general catalytic properties, J. Biol. Chem., 238: 3024.
Holmes, E.W., 1980, Kinetic, physical, and regulatory properties of amido phosphoribosyl transferase, Adv. Enz. Reg., 19: 215.
Holmes, E.W., Wyngaarden, J.B., and Kelley, W.N., 1973, Human glutamine phosphoribosylpyrophosphate amidotransferase: two molecular forms interconvertible by purine nucleotides and phosphoribosylpyrophosphate., J. Biol. Chem., 248: 6035.
Rowe, P.B., and Wyngaarden, J.B., 1968, Glutamine phosphoribosyl pyrophosphate amidotransferase: purification, sub-structure, amino acid composition and absorption spectra, J. Biol. Chem., 243: 6373.
Sant, M.E., Lyons, S.D., Phillips, L., and Christopherson, R.I., 1992, Antifolates induce inhibition of amido phosphoribosyltransferase in leukaemia cells, J. Biol. Chem., 267: 11038.
Sant, M.E., Poiner, A., Harsanyi, M.C., Lyons, S.D., and Christopherson, R.I., 1989, Chromatographic analysis of purine precursors in mouse L1210 leukaemia, Anal. Biochem., 182: 121.
Schendel, F.J., Cheng, Y.S., Otvos, J.D., Wehrli, S., and Stubbe, J., 1988, Characterisation and chemical properties of phosphoribosylamine, an unstable intermediate in the de novo purine biosynthetic pathway, Biochemistry, 27: 2614.
Shen, Y. Rudolph, J., Stern, M., and Stubbe, J., 1990, Glycinamide ribonucleotide synthetase from Escherichia coli: cloning, overproduction, sequencing, isolation, and characterisation, 29: 218.
Zhou, G., Dixon, J.E., and Zalkin, H., 1990, Cloning and expression of avian glutamine phosphoribosylpyrophosphate amidotransferase, J. Biol. Chem., 265: 21152.
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Schoettle, S.L., Christopherson, R.I. (1995). Inhibition of Murine Amido Phosphoribosyltransferase by Folate Derivatives. In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2584-4_34
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DOI: https://doi.org/10.1007/978-1-4615-2584-4_34
Publisher Name: Springer, Boston, MA
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