Abstract
2-chloro-2’-deoxyadenosine (2CdA), a new anticancer drug has been introduced as therapy against some kinds of leukemia, i.e. hairy cell leukemia and chronic lymphocytic leukemia (CLL). According to published data this drug induces cell apoptosis1 and the mechanism of 2CdA cytotoxicity leads via phosphorylated derivatives to inhibition of DNA synthesis which involves ribonucleotide reductase, DNA polymerases and DNA repair2.
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© 1995 Springer Science+Business Media New York
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Fabianowska-Majewska, K. et al. (1995). A New Mechanism of Toxicity of 2-Chlorodeoxyadenosine (2CdA). In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2584-4_28
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DOI: https://doi.org/10.1007/978-1-4615-2584-4_28
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