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Renal Clearances of Purine Bases and Oxypurinol During Glucose Infusion

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 370))

Abstract

Glucose infusion causes increased excretion of uric acid1, 2, suggesting a functional relationship between the renal handling of uric acid and glucose. Furthermore, some functional association between the renal transport of uric acid, oxypurines and oxypurinol have been suggested3, 4. However, the effect of glucose infusion on the renal transport of oxypurines and oxypurinol, an allopurinol metabolite, has not yet been investigated, to our knowledge. Therefore, we examined the response of renal clearances of purine bases and oxypurinol to intravenous glucose infusion.

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References

  1. R.W. Bonsnes, E.S. Dana: On the increased uric acid clearance following the intravenous infusion of hypertonic glucose solutions. J. Clin Invest 25:386(1946).

    Article  CAS  Google Scholar 

  2. P.J. Christensen, O.R. Steenstrup: Uric acid excretion with increasing plasma glucose concentration (pregnant and non-pregnant cases). Scand J Clin Lab Invest 10:182 (1958).

    Article  PubMed  CAS  Google Scholar 

  3. T. Yamamoto, Y. Moriwaki, S. Takahashi, T. Hada, K. Higashino: Renal excretion of purine bases-Effects of probenecid, benzbromarone and pyrazinamide. Nephron 48:116(1988).

    Article  PubMed  CAS  Google Scholar 

  4. K. Kaneko, S. Fujimori, H. Itoh: Renal handling of hypoxanthine and xanthine in normal subjects and in four cases of idiopathic renal hypouricemia. J. Rheumatol 15:325(1988).

    PubMed  CAS  Google Scholar 

  5. T. Yamamoto, Y. Moriwaki, S. Takahashi, T. Hada, K. Higashino: Separation of hypoxan thine and xanthine from pyrazinamide and its metabolites in plasma and urine by highperformance liquid chromatography. J. Chromatogr 382:270(1986).

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  6. G. Boner, R.E. Rieselbach: Effect of glucose upon reabsorptive transport of urate by the kidney. Adv Exp Med Biol 41B:781(1977).

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© 1995 Springer Science+Business Media New York

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Moriwaki, Y., Yamamoto, T., Takahashi, S., Nasako, Y., Hada, T., Higashino, K. (1995). Renal Clearances of Purine Bases and Oxypurinol During Glucose Infusion. In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2584-4_10

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  • DOI: https://doi.org/10.1007/978-1-4615-2584-4_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6105-3

  • Online ISBN: 978-1-4615-2584-4

  • eBook Packages: Springer Book Archive

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