Actin pp 191-203 | Cite as

Redistribution of p52(PAI-1) mRNA to the Cytoskeletal Framework Accompanies Increased p52(PAI-1) Expression in Cytochalasin D-Stimulated Rat Kidney Cells

  • Paul J. Higgins
  • Michael P. Ryan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 358)


Cellular morphology is determined largely by cell-to-cell and cell-to-extracellular matrix (ECM) contacts as well as by structural constraints imposed by the organization of the internal cytoskeleton (Ingber, 1991; Harris, 1987; reviewed in Ingber and Folkman, 1989). These interrelated parameters appear to be important in the regulation of cell function. Thus, initiation of DNA synthesis is directly related to extent of cell spreading (Maroudas, 1973a,b; Folkman and Moscona, 1978; Ingber et al., 1987) and cell shape strongly influences differentiated function (e.g., Clayton et al., 1985; Bissell et al., 1982; Ben-Ze’ev, 1986; Hay and Svoboda, 1989; Ben-Ze’ev and Amsterdam, 1987; Reid, 1990; Watt et al., 1988; Chen and Bissell, 1989) while changes in actin microfilament organization accompany cellular growth activation (Schlessinger and Geiger, 1981; Bockus and Stiles, 1984; Ryan and Higgins, 1993) and transduction of intracellular signals (reviewed in Ben-Ze’ev, 1992). The existance of such potential configuration-dependent controls in cultured cells highlights the relationship between cell shape and gene expression (Hay and Svoboda, 1989; Ben-Ze’ev and Amsterdam, 1987; Blum and Wicha, 1988; Li et al., 1987; Canfield et al., 1990).


mRNA Species Cell Shape Change Albany Medical College Cytoskeletal Framework Subcellular Partitioning 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Paul J. Higgins
    • 1
  • Michael P. Ryan
    • 1
  1. 1.Department of Microbiology Immunology and Molecular GeneticsAlbany Medical CollegeAlbanyUSA

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