Actin Filaments and the Spatial Positioning of mRNAS
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Filamentous actin has been shown to play a major role in the control of mRNA expression. Previous work emphasized RNA-cytoskeletal interactions using biochemical fractionation. More recently, in situ hybridization at the light microscopic and ultrastructural levels has shown that actin, in particular, is directly associated with mRNAs. It is proposed that these interactions play a major regulatory role in how the mRNA is spatially sequestered within the cytoplasm and provide a mechanism for its regulation (Singer, 1992).
KeywordsActin Filament Cytoplasmic Compartment Actin mRNA Actin Isoforms Cell BioI
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