Gelsolin Expression in Normal Human Keratinocytes is a Function of Induced Differentiation
The epidermis is a self-renewing tissue comprised mainly of keratinocytes that exhibit different degrees of maturation depending upon their location (i.e. basal or suprabasal) within the tissue 1,2. Under non-perturbed conditions, the turnover rate within the epidermis is relatively slow and the keratinocytes exist primarily in a non-migratory mode with cells exhibiting attachment to the basement membrane and to other surrounding cells via families of surface receptors known as integrins and cadherins3,4. Upon partial or full thickness injury, keratinocytes become activated and assume a migratory phenotype5. This activation process includes modulation of integrin expression, actin reorganization and changes within the complement of actin-associated proteins that enable the keratinocyte to migrate over and through the provisional wound matrix to re-establish a complete epithelial barrier.
KeywordsTerminal Differentiation Human Epidermal Keratinocytes Basal Keratinocytes Normal Human Keratinocytes Cornified Envelope
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