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Actin pp 147-157 | Cite as

Changes in Adhesion Plaque Protein Levels Regulate Cell Motility And Tumorigenicity

  • Avri Ben-Ze’ev
  • José Luis Rodríguez Fernández
  • Ursula Glück
  • Daniela Salomon
  • Benjamin Geiger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 358)

Abstract

Cell adhesion to neighboring cells and to the extracellular matrix (ECM) plays a major role in cell and tissue morphogenesis (Edelman, 1992; Takeichi, 1991; Hynes, 1992). These complex, adhesion-related cellular processes are mediated through transmembrane contact receptors of the cadherin and integrin families of receptors (Takeichi, 1991; Hynes, 1992). In the cytoplasmic domain, these receptors interact with cytoskeletal plaque proteins such as vinculin, talin and α-actinin which anchor the microfilament system to junctional areas in adherens type junctions (AJ) in adhesion plaques, and to α and β catenin and plakoglobin in cell-cell AJ (Burridge et al., 1988; Geiger and Ginsberg, 1991; Geiger et al., 1992). The cascade of molecular interactions which links the outside to the inside of the cell defines cell shape and motility, and also has a function in signal transduction which results in effects on cell growth, differentiation, and gene expression (Ben-Ze’ev, 1991; 1992; Schwartz, 1992; Haskill and Juliano, 1993). Signaling through adhesion plaques is suggested to occur through changes in tyrosine phosphorylation (Burridge et al., 1992; Volberg et al., 1992). Moreover, recent studies have demonstrated that the changes in tyrosine phosphorylation of a cytoplasmic adhesion plaque tyrosine kinase (p125FAK) is common to adhesion related signaling and to growth factor, cytokine and neuropeptide induced signaling (Zachary and Rozengurt, 1992), and that tyrosine phosphorylation of p125FAK is constitutively activated in oncogene-transformed cells (Guan and Shalloway, 1992). These results suggest a convergence, in adhesion plaques, of signals transduced by cytokines, oncogenes and adhesion.

Keywords

Tyrosine Phosphorylation Adhesion Plaque Transfected Clone Tumorigenic Ability Syngeneic Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Avri Ben-Ze’ev
    • 1
  • José Luis Rodríguez Fernández
    • 1
  • Ursula Glück
    • 1
  • Daniela Salomon
    • 2
  • Benjamin Geiger
    • 2
  1. 1.Department of Molecular Genetics and VirologyWeizmann Institute of ScienceRehovotIsrael
  2. 2.Chemical ImmunologyWeizmann Institute of ScienceRehovotIsrael

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