Actin Filament Dynamics in Cell Motility
The motility of individual animal cells is important for a wide variety of basic biological processes including rearrangements during embryonic development, neurite outgrowth, wound healing, inflammation, and cancer metastasis. The actin cytoskeleton in animal cells must also drastically rearrange in a cell-cycle dependent manner in order to perform cytokinesis. Actin microfilament dynamics are intimately involved in all of these common types of cell motility, but the mechanisms of force transduction and movement are still poorly understood.
KeywordsActin Filament Actin Polymerization Comet Tail Actin Monomer Filament Polymerization
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