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Actin pp 113-122 | Cite as

Caldesmon: Possible Functions in Microfilament Reorganization During Mitosis and Cell Transformation

  • Shigeko Yamashiro
  • Kyonsoo Yoshida
  • Yoshihiko Yamakita
  • Fumio Matsumura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 358)

Abstract

Microfilaments are intimately involved in the morphological alterations observed both in cell transformation and mitosis. In both cases, microfilamenets show significant re-organization. While “normal” cells with well-spread morphologies have numerous bundles of microfilaments, transformed cells with rounded morphologies show dispersed microfilament patterns1. These changes in the structure of actin cables, as well as in substrate adhesion, are closely coupled with proliferation in both normal and transformed cells1, suggesting that the microfilament cytoskeleton may play an important role in oncogenic transformation. The process of cell division causes similar alterations in microfilament patterns to those seen in transformed cells. Microfilament bundles disassemble when cells become rounded-up during prophase2,3 resulting in a cytoarchitecture resembling the dispersed microfilament patterns seen in the many transformed cell types which exhibit rounded morphologies. Microfilament bundles that are anchored to focal contacts are also disrupted in both mitotic and transformed cells, causing reduced adhesion of such cells to their substrates. These observations suggest that cell transformation and cell division control are intimately related, not just superficially, but at the level of molecular control.

Keywords

Cell Transformation Actin Binding Chicken Embryo Fibroblast Cdc2 Kinase Rounded Morphology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Shigeko Yamashiro
    • 1
  • Kyonsoo Yoshida
    • 1
  • Yoshihiko Yamakita
    • 1
  • Fumio Matsumura
    • 1
  1. 1.Department of Molecular Biology and Biochemistry, Nelson Labs/busch Campus Rutgers UniversityPiscatawayUSA

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