Actin Regulation and Surface Catalysis
- 85 Downloads
The motile behavior of non-muscle cells often differs between healthy and pathological conditions. Two disease processes, cancer and atherosclerosis, are associated with high morbidity and mortality in our society. The cells involved in both the pathogenesis of and me defense against these diseases undergo marked changes in the organization of their actin cytoskeletonl1,2. In response to a signal originating from the extracellular space, from surrounding cells, or as the result of a mutation, diseased cells initiate a process of motion away from their normal location. Local growth inhibitors are lost, and displaced cells undergo unchecked proliferation1. One example of such a phenomenon is the migration of fibroblasts and smooth muscle cells into the vascular intima and their proliferation in patients with atherosclerotic coronary artery disease2. Another example is the proliferation of metastatic cells distant from the site of primary tumor1.
KeywordsActin Filament Actin Cytoskeleton Calcium Transient Actin Stress Fiber Actin Monomer
Unable to display preview. Download preview PDF.
- 2.Heldman AW, Furman MI, Gardner TM, Gips SJ, Crawford LE, Goldschmidt-Clermont PJ, Coronary artery disease and atherogenesis. in: Molecular Basis of Medicine, Dang CV and Feldman AM, eds., (1993) in press.Google Scholar
- 4.Howard K, Getting there? Curr Biol. 3: 103 (1993).Google Scholar
- 11.Finkel T, Theriot JA, Dise KR, Tomaselli GF, Goldschmidt-Clermont PJ, Actin superstructure promoted by profilin. Proc Natl Acad Sci USA (1993) in press.Google Scholar
- 28.Bourne HR, Sanders DA, McCormick F, The GTPase superfamily: conserved structure and molecular mechanism. Nature 349: 117 (1991)Google Scholar
- 30.Acknowledgements: This research was supported in part by a grant from Syntex, by a grant from the Bernard Foundation and by the American heart Association (G-I-A, Maryland Affiliate, Inc.). PJG-C was selected as a Syntex Scholar in 1992.Google Scholar