Actin pp 3-12 | Cite as

Vibrational Modes of G-Actin

  • Monique M. Tirion
  • Daniel ben-Avraham
  • Kenneth C. Holmes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 358)


The determination of the atomic structure of g-actin (Kabsch et al., 1990, see Fig. 1) allowed the development of an atomic model for f-actin (Holmes et al., 1990). The structure of f-actin was deduced from x-ray diffraction patterns from bundles of aligned actin filaments, using the known helical symmetry of the filament and keeping the atomic structure of the monomer fixed. The model of f-actin was obtained, therefore, using only four structural parameters: three rotational and one radial degree of freedom. The solution thus obtained is unique, and achieved an R-factor of.22; an extremely good fit with such few parameters.


Normal Mode Slow Mode Normal Mode Analysis Binding Loop Hinge Point 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Monique M. Tirion
    • 1
  • Daniel ben-Avraham
    • 1
  • Kenneth C. Holmes
    • 2
  1. 1.Physics DepartmentClarkson UniversityPotsdamUSA
  2. 2.Max-Planck-Institute for Medical ResearchHeidelbergGermany

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