Abstract
Substance P (SP) has been established as an excitatory neuromodulator in the cat carotid body (CB) (Prabhakar et al., 1987; 1989). These workers have suggested that SP may be an important link between the transduction mechanism for hypoxia and the production of afferent neural discharge.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Brattstrom, A. &Seidenbecher, T. (1992). Central substance P increased blood pressure, heart rate and splanchnic nerve activity in anaesthetized rats without impairment of the baroreflex regulation. Neuropeptides 23:81–86.
Chen, Z, Hedner, J. &Hedner, T. Substance P in the ventrolateral medulla oblongata regulates ventilatory responses. (1990). J. Appl. Physiol. 68:2631–2639.
Lundberg, J.M. &Saria, A. (1987). Polypeptide containing neurons in airway smooth muscle. Ann. Rev. Physiol. 49:555–572.
Pernow, B. (1983). Substance P. Pharmacological Rev. 35:85–141.
Prabhakar, N.R., Landis, S.C., Kumar, G.K., Mullikin-Kilpatrick, D., Cherniack, N.S. &Leeman, S. (1989). Substance P and neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial PO2-Brain Res. 481:205–214.
Prabhakar, N.R., Mitra, J. &Cherniack, N.S. (1987). Role of substance P in hypercapnic excitation of carotid chemoreceptors. J. Appl. Physiol. 63:2418–2425.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Bisgard, G.E., Pizarro, J., Ryan, M., Hedrick, M. (1994). Substance P Inhibits Ventilation in the Goat. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_46
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2572-1_46
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6099-5
Online ISBN: 978-1-4615-2572-1
eBook Packages: Springer Book Archive