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Activation of GTP-Binding Proteins by Aluminum Fluoride Modulates Catecholamine Release in the Rabbit Carotid Body

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Arterial Chemoreceptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 360))

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Abstract

The involvement of GTP-binding proteins (G proteins) in the regulation of stimulussecretion coupling is extensively documented in a great number of preparations (Gomperts, 1990), and an important regulatory role for G proteins has been described in the transduction process of gustatory and olfactory chemoreceptors (Lancet, 1986; Bruch, 1990). However in the carotid body (CB) chemoreceptor cells, no attempts have been made to clarify the nature and the function of G proteins, although the involvement of second messenger systems in the release of catecholamines (CA) and in the chemoreceptor response (Pérez-García et al., 1991; Gómez-Niño et al., 1992) suggest a modulatory role for G proteins in the transduction-transmission processes in the arterial chemoreceptors.

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© 1994 Springer Science+Business Media New York

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Cachero, M.T.G., Rocher, A., Rigual, R.J., Gonzalez, C. (1994). Activation of GTP-Binding Proteins by Aluminum Fluoride Modulates Catecholamine Release in the Rabbit Carotid Body. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_29

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  • DOI: https://doi.org/10.1007/978-1-4615-2572-1_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6099-5

  • Online ISBN: 978-1-4615-2572-1

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