Abstract
It is generally accepted that endothelial cells lining the inner surface of the vascular tree release vasoactive substances in response to low critical values of the arterial oxygen partial pressure. Although much is known about the electrical membrane properties of endothelial cells (Revest & Abbott, 1992) less is known about the intimate transduction mechanism which initiates O2-chemoreception. Ionic currents of endothelial cells from rat brain capillaries were studied in voltage-clamp experiments to find out whether the response to hypoxia could be also related to changes in the membrane conductance as known on carotid body type-I cells (Lopez-Barneo et al., 1988; Hescheler et al., 1989). Here, it is shown that endothelial cells from rat brain capillaries contain PO2-modulated K+ channels.
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© 1994 Springer Science+Business Media New York
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Delpiano, M.A. (1994). Ionic Currents on Endothelial Cells of Rat Brain Capillaries. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_24
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DOI: https://doi.org/10.1007/978-1-4615-2572-1_24
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