Abstract
The carotid body detects chemical changes in the blood such as PO2, PCO2 and pH, and generates afferent discharges in the carotid nerve. During stimulation, the glomus cells release endogenous substances (ACh, catecholamines, and neuropeptides) toward the carotid nerve terminals. To understand how secretion occurs, we have studied the electric connections between glomus cells at rest and during activity elicited by ‘natural’ stimuli, or the transmitters (Monti-Bloch et al., 1990, 1993). In other secretory organs, adjoining cells are electrically coupled and they uncouple (fully or partially) during secretion (for refs. see Bennett & Spray, 1985; Hertzberg & Johnson, 1988; Bennett et al., 1991).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bennett, M.V.L.(1966). Physiology of electronic junctions. Ann. N. Y. Acad. Sci. 137:509–539
Bennett, M.V.L., Barrio, L. C., Bargiello, T. A., Spray, D. C., Hertzberg, E. &Saez, J. C. (1991). Gap junctions : New tools, new answers, new questions. Neuron 6:305–320.
Bennett, M.V.L. &Spray, D. C. (1985). “Gap Junctions”, Cold Spring Harbor Laboratory.
Biscoe, T. J., Duchen, M. R., Eisner, D. A., O’Neill, S. C. &Valdeolmillos, M. (1989). Measurements of intracellular Ca2+ in dissociated type I cells of the rabbit carotid body. J. Physiol. (Lond.) 416:421–434.
Buckler, K. J., Vaughan-Jones, R. D., Peers, C. &Nye, P. C. G. (1991). Intracellular pH and its regulation in isolated type I carotid body cells of the neonatal rat. J. Physiol. (Lond.) 436:107–129.
Donnelly, D. F. &Kholwadwala, D. (1992). Hypoxia decreases intracellular calcium in adult rat carotid body glomus cells. J. Neurophysiol. 67:1543–1551.
Eyzaguirre, C., Monti-Bloch, L., Baron, M., Hayashida, Y. &Woodbury, J. L., (1989). Changes in glomus cell membrane properties in response to stimulants and depressants of carotid nerve discharge. Brain Res. 477:265–279.
Eyzaguirre, C., Monti-Bloch, L. &Woodbury, J. W. (1990). Effects of putative neurotransmitters of the carotid body on its own glomus cells. Eur. J. Neurosci. 2:77–88.
Fidone, S. J. &Gonzalez, C. (1986). Initiation and control of chemoreceptor activity in the carotid body, In: Handbook of Physiology, The Respiratory System, Vol. II, sect 3, Am Physiol. Soc., Bethesda, MD.
Flagg-Newton, J. L., Dahl, G &Loewenstein, W. R. (1981). Cell junction and cyclic AMP. I. Upregulation of junctional membrane permeability and junctional membrane particles by cyclic nucleotide treatments. J. Membr. Biol. 63:105–121.
Hax, W. M. A., Van Venrooji, G. E. &Vossenberg, J. B. (1974). Cell communication: A cyclic AMP-mediated phenomenon. J. Membr. Biol. 19:253–266.
He, S.-F., Wei, J.-Y. &Eyzaguirre, C. (1990). Intracellular pH of cultured carotid body cells. In “Arterial Chemoreception”, C. Eyzaguirre, S. J. Fidone, R. S. Fitzgerald, S. Lahiri and D. M. McDonald, eds., SpringerVerlag, New York.
He, S.-F., Wei, J.-Y. &Eyzaguirre, C. (1991a). Intracellular pH and some membrane characteristics of cultured carotid body cells. Brain Res. 547:258–286.
He, S.-F., Wei, J.-Y. &Eyzaguirre, C. (1991b). Effects of relative hypoxia and hypercapnia on intracellular pH and membrane potential of cultured carotid body cells. Brain Res. 556:333–338.
Hertzberg, E. L. &Johnson, R. G. (1988). Gap Junctions. In “Modern Cell Biology”, vol. 7, Alan R. Liss, New York.
Iturriaga, R., Rumsey, W. L., Lahiri, S., Spergel, D. &Wilson, D. F. (1992). Intracellular pH and oxygen chemoreception in the cat carotid body in vitro. J. Appl. Physiol. 72:2259–2262.
Kessler, J. A., Spray, D. C., Saenz, J. C. &Bennett, M. V. L. (1985). Development and regulation of electrotonic coupling between cultured sympathetic neurons. In “Gap Junctions”, M. V. L. Bennett and D. C. Spray, eds Cold Spring Harbour Laboratory.
Lasater, E. M. &Dowling, J. E. (1985). Electric coupling between pairs of isolated fish horizontal cells is modulated by dopamine and cAMP. In “Gap Junctions”, M. V. L. Bennett and D. C. Spray, eds., Cold Spring Harbour Laboratory.
McDonald, D. M. (1991. Peripheral chemoreceptors: structure-function relationships of the carotid body. In “Regulation ofBreathing”, T. F. Hornbein, ed., vol. 17 of “Lung Biology in Health and Disease”. C. Lenfant, exec, ed., Marcel Decker, New York.
Monti-Bloch, L. &Eyzaguirre, C. (1990). Effects of natural stimuli, chemical agents and transmitters on glomus cell membranes and intracellular communications. In “Arterial Chemoreception”, C. Eyzaguirre, S. J. Fidone, R. S. Fitzgerald, S. Lahiri and D. M. McDonald, eds., Springer-Verlag, New York.
Monti-Bloch, L., Abudara, V. &Eyzaguirre, C. (1993). Electrical communication between glomus cells of the rat carotid body. Brain Res. in press.
Neyton, J., Piccolino, M. &Gerschenfeld, H. M. (1985). Neurotransmitter-induced modulation of gap junction permeability in retinal horizontal cells. In “Gap Junctions”, M. V. L. Bennett and D. C. Spray, eds., Cold Spring Harbour Laboratory.
Sato, M., Ikeda, K., Yoshizaki, K. &Koyano, H. (1991). Response of cytosolic calcium to anoxia and cyanide in cultured glomus cells of newborn rabbit carotid body. Brain Res. 551:327–330.
Sperelakis, N. &Cole, W. C. (1989). “Cell Interations and Gap Junctions”, CRC Press.
Spray, D. C. &Bennett, M. V. L. (1985). Physiology and pharmacology of gap junctions. Ann. Rev. Physiol. 47:281–303.
Wang, W. J., Cheng, G. F., Yoshizaki, K., Dinger, B. &Fidone, S. (1991). The role of cyclic AMP in chemoreception in the rabbit carotid body. Brain Res. 540:96–104.
Wilding, T. J., Cheng, B. &Roos, A. (1992). pH regulation in adult rat carotid body glomus cells. J. Gen. Physiol. 100:593–608.
Zhang, X.-Q., Pang. L. &Eyzaguirre, C. (1992). Effects of hypoxia induced by Na2S2O4 on K+ and Ca2+ activities of cultured carotid body glomus cells. Soc. Neurosci. Abstr. 18:1198.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Monti-Bloch, L., Abudara, V., Eyzaguirre, C. (1994). Electrotonic Coupling between Carotid Body Glomus Cells. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_15
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2572-1_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6099-5
Online ISBN: 978-1-4615-2572-1
eBook Packages: Springer Book Archive