Abstract
It is well established today that arterial and central receptors sensitive to CO2 and H+ can affect breathing. However, it is likewise appreciated that these receptors alone cannot explain the adaptive changes of respiration in all experimental and natural conditions, particularly not during mild and moderate exercise, when both arterial (and probably central) PCO2 and [H+] are decreased and thus ruled out as stimuli for exercise hyperpnea. The theory of Zuntz & Geppert (1886) of receptors sensitive to the PCO2 in mixed venous blood has, therefore, long remained attractive (see Dejours, 1964) since mixed venous PCO2 is certainly increased even during mild exercise. However, positive evidence for the existence of such receptors in mammals has never been provided.
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Scheid, P., Shams, H. (1994). Chemosensitivity from the Lungs of Vertebrates. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_11
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DOI: https://doi.org/10.1007/978-1-4615-2572-1_11
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