Evidence that Uric Acid Abolishes Citrate-Mediated Inhibition of Calcium Oxalate Monohydrate Agglomeration in Vitro
Calcium oxalate monohydrate (COM) crystal growth and agglomeration in urine are modulated by a complex set of chemical and physical properties of the medium. In such a chemically complex milieu, where many effects of these properties can mask each other, it is virtually impossible to identify and/or quantify them separately. However, considerable advantage can be gained in the understanding of the mechanisms involved by testing the effects of some of the species present in urine in isolation, or in combination with only a small number of other urinary constituents.
KeywordsCrystallization Citrate Dimethyl Oxalate Agglomeration
Unable to display preview. Download preview PDF.
- 3.S Volta, E Fradinger, C Bogado, J Zanchetta, Mecanismos de accion de inhibidores y promotores de la cinetica de cristalizacion del oxalato de calcio monohidrato (COM), Medicina 51(5), 443 (1991).Google Scholar
- 4.L Blomen, Growth and agglomeration of calcium oxalate monohydrate, Thesis, Leiden University, (1982).Google Scholar
- 5.D Kok, The role of crystallization processes in calcium oxalate urolithiasis, Thesis, Leiden University (1991).Google Scholar
- 7.FL Coe, Commentary: Allopurinol treatment of uric-acid disorders in calcium stone formers, J Lithotripsy and Stone Dis 3(3), 272 (1991).Google Scholar