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Urolithiasis 2 pp 223-224 | Cite as

Oral Cimetidinein Humans - Evidence For Urine Acidification and Inhibition of Calcium Oxalate Crystallization

  • U. Herrmann
  • P. O. Schwille
  • M. Manoharan
  • H. Gruber
  • A. Wenig

Abstract

Medication of subgroups of idiopathic calcium urolithiasis often aims at reducing an alkaline or insufficiently acidic urinary pH. Since (exogenous) acid loading is effective but instantly attacks the body’s buffer reservoirs, we tested the hypothesis that inhibition of postprandial gastric proton release into the gastric lumen may lead to proton diversion to kidney via blood, and to subsequent excretion via urine.

Keywords

Primary Hyperparathyroidism Calcium Oxalate Acid Loading Stone Patient Subsequent Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Reference

  1. 1.
    GA Williams, RS Longley, EN Bowser et al, Parathyroid hormone secretion in normal man and in primary hyperparathyroidism: Role of histamine H2 receptors. J Clin Endocrinol Metab 52: 122 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • U. Herrmann
    • 1
  • P. O. Schwille
    • 1
  • M. Manoharan
    • 1
  • H. Gruber
    • 1
  • A. Wenig
    • 1
  1. 1.Mineral Metabolism and Endocrine Research Laboratory, Departments of Surgery and UrologyUniversity of ErlangenGermany

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