Urolithiasis 2 pp 197-199 | Cite as

The Effect of Urate on Calcium Oxalate Precipitates

  • K. Kleboth
  • J. Joost


Despite numerous investigations, the role of uric acid in calcium oxalate monohydrate (COM) lithiasis is still speculative. Heterogeneous nucleation and epitaxial growth, specific adsorption of COM growth inhibitors, and salting out effects have been suggested to explain the apparent influence of uric acid and urates on the precipitation of COM1. Coprecipitation and mixed crystal formation of COM with urates have also been proposed, based upon the comparison of crystallographic data2. Evidence for epitaxial growth of COM on uric acid and sodium hydrogen urate (NaHU) has been presented3. In this paper we describe co-precipitation and mixed crystal formation experiments of COM with Ca(HU)2.


Uric Acid Epitaxial Growth Heterogeneous Nucleation Calcium Oxalate Seed Crystal 
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    LJMJ Blomen and AAB Lycklama ⃡ Nijeholt, Die Bedeutung der Harnsaure und der Urate fü,r die Kristallisation von Kalziumoxalatsteinen, in: “Hamsäure und Urolithiasis”, GIT Verlag, Darmstadt (1984).Google Scholar
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    NS Mandel and GS Mandel, Epitaxis between stone forming crystals at the atomic level, in: “Urolithiasis, Clinical and Basic Research”, Springer Science+Business Media New York and London (1981).Google Scholar
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    H-G Tiselius, Effects of sodium urate and uric acid crystals on the crystallization of calcium oxalate, Urol Res 12: 11–15 (1984).PubMedCrossRefGoogle Scholar
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    ME Sheehan and GH Nancollas, Calcium oxalate crystal growth, Invest Urol 17: 446.Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • K. Kleboth
    • 1
  • J. Joost
    • 2
  1. 1.Institute of Inorganic and Analytical ChemistryUniversity of InnsbruckAustria
  2. 2.Department of UrologyHall i.TAustria

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