Erythrocyte Band 3 Protein Phosphorylation Modulates Anion Transport in Nephrolithiasic Patients
Higher oxalate1, and urate2 transmembrane self-exchange rates, and a faster endogenous phosphorylation of band 3 protein3, the anion carrier, were found in red cells from idiopathic calcium-oxalate renal stone formers. That these two cellular-abnormalities might be linked is an attractive hypothesis, but it is still debated whether anion transport modulation involves the phosphorylation of band 3 and other membrane proteins. To investigate this problem further, we studied the effect of agents known to interfere with membrane protein phosphorylation on anion transport.
KeywordsAnion Transport Phorbol Myristate Acetate Anion Carrier Calcium Nephrolithiasis NEPHROLITHIASIC Patient
- 2.G Gambaro, F Marchini, M Vincenti et al, Erythrocyte urate self-exchange in idiopathic calcium nephrolithiasis. In this volume.Google Scholar
- 3.B Baggio, G Clari, G Marzaro et al, Altered red blood cell membrane protein phosphorylation in idiopathic calcium oxalate nephrolithiasis. IRCS Med Sci 14: 368 (1986).Google Scholar